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Elucidation of the mechanism of transplanted rejected airways with special reference to epithelial to mesenchymal transition

Research Project

Project/Area Number 22591560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

MURAKAWA Tomohiro  東京大学, 医学部附属病院, 講師 (50359626)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Jun  東京大学, 医学部附属病院, 教授 (90188954)
SANO Atsushi  東京大学, 医学部附属病院, 助教 (20569834)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords呼吸器外科学 / 移植 / 線維化 / 閉塞性細気管支炎 / 上皮間葉移行 / 気道リモデリング / 肺移植
Research Abstract

We confirmed that epithelial to mesenchymal transition had some roles in transplanted rejected airways using histological assessment of changes over time. On the other hand, our results using transgenic mice revealed that the fibroblasts in fibrosis of transplanted airways originated from the recipient. This suggests that blocking fibroblasts differentiation from recipient bone marrow precursor cells may lead to preventing fibrosis in transplanted organs.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (20 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors.2013

    • Author(s)
      Hideki Kuwano, Takehiro Tsuchiya, Tomonori Murayama, Atsushi Sano, Kazuhiro Nagayama, Yukihiro Yoshida, Tomohiro Murakawa, Jun Nakajima.
    • Journal Title

      Surgery Today

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ground glass opacity component can be eliminated from the T-factor assessment of lung adenocarcinoma.2013

    • Author(s)
      Tomohiro Murakawa, Chihiro Konoeda,Takuya Ito, Yuta Inoue, Atsushi Sano, Kazuhiro Nagayama, Jun Nakajima.
    • Journal Title

      European journal of cardio-thoracicsurgery.

      Volume: 43(5) Issue: 5 Pages: 925-932

    • DOI

      10.1093/ejcts/ezs467

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial to Mesenchymal Transition in Murine Tracheal Allotransplantation: An Immunohistochemical Observation.2013

    • Author(s)
      Chihiro Konoeda
    • Journal Title

      Transplantation Proceedings

      Volume: - Issue: 5 Pages: 1797-1801

    • DOI

      10.1016/j.transproceed.2012.11.024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain andthe common γ-chain.2013

    • Author(s)
      Izumi T, Kondo M, Takahashi T, Fujieda N, Kondo A, Tamura N, Murakawa T, Nakajima J, Matsushita H, Kakimi K.
    • Journal Title

      Cytotherapy

      Volume: 15(4) Issue: 4 Pages: 481-491

    • DOI

      10.1016/j.jcyt.2012.12.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors2013

    • Author(s)
      Hideki Kuwano
    • Journal Title

      Surgery Today

      Volume: - Issue: 3 Pages: 499-504

    • DOI

      10.1007/s00595-013-0562-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial to Mesenchymal Transition in Murine Tracheal Allotransplantation: An Immunohistochemical Observation.2012

    • Author(s)
      Chihiro Konoeda, Daizo Koinuma, Yasuyuki Morishita, Atsushi Sano,Kazuhiro Nagayama, Noboru Motomura, Kazuhiro Kakimi, Kohei Miyazono, Jun Nakajima, Tomohiro Murakawa.
    • Journal Title

      Transplantation Proceedings.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer.2012

    • Author(s)
      Takuya Ito, Tomohiro Murakawa, HajimeSato, Aska Tanabe, Masaki Maekawa, Yukihiro Yoshida, Masashi Fukayama, Jun Nakajima.
    • Journal Title

      Interactive Cardiovascular and Thoracic Surgery.

      Volume: 15(4) Pages: 633-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer.2012

    • Author(s)
      Takuya Ito
    • Journal Title

      Interactive Cardiovascular and Thoracic Surgery.

      Volume: 15(4) Issue: 4 Pages: 633-638

    • DOI

      10.1093/icvts/ivs163

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.2011

    • Author(s)
      Kentaro Kitano, Kousuke Watanabe,Noriko Emoto, Hidenori Kage, Emi Hamano, Takahide Nagase, Atsushi Sano, Tomohiro Murakawa, Jun Nakajima, Akiteru Goto, Masashi Fukayama, Yutaka Yatomi, Nobuya Ohishi, Daiya Takai.
    • Journal Title

      Cancer Science

      Volume: 102(12)2126-31 Pages: 1349-7006

    • NAID

      10030245653

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer2011

    • Author(s)
      Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 12 Pages: 2126-2131

    • DOI

      10.1111/j.1349-7006.2011.02101.x

    • NAID

      10030245653

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome and survival analysis of pulmonary metastasectomy for hepatocellular carcinoma2011

    • Author(s)
      Kitano K, Murayama T, Sakamoto M, Nagayama K, Ueno K, Murakawa T, Nakajima J
    • Journal Title

      European Journal of Cardiothoracic Surgery

      Volume: 41(2) Issue: 2 Pages: 376-82

    • DOI

      10.1016/j.ejcts.2011.05.052

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung lobectomy in a patient with an implantable left ventricular assist device2011

    • Author(s)
      Murakawa T, Murayama T, Nakajima J, Ono M
    • Journal Title

      Interactive Cardiovascular and Thoracic Surgery

      Volume: 13(6) Issue: 6 Pages: 676-678

    • DOI

      10.1510/icvts.2011.281493

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resection of a posterior mediastinal metastasis of colon cancer2011

    • Author(s)
      Sano A, Murakawa T, Morota T, Nakajima J
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 92(1) Issue: 1 Pages: 353-354

    • DOI

      10.1016/j.athoracsur.2011.01.041

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【肺癌-パラダイムシフトを迎えた肺癌治療】肺癌において期待される新しい治療 肺がんに対する免疫療法(免疫細胞療法とがんペプチドワクチン療法)(解説/特集)2011

    • Author(s)
      中島淳
    • Journal Title

      カレントテラピー

      Volume: 29 Pages: 1039-1044

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Life-threatening tracheal perforation secondary to descending necrotizing mediastinitis.2010

    • Author(s)
      Murakawa T, Yoshida Y, Fukami T, Nakajima J
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 10 Pages: 454-456

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumothorax after left pneumonectomy : accentuated negative pressure at azygoesophageal recess by a mediastinal shiftft and rotation.2010

    • Author(s)
      Takahashi T.Murakawa T, Fukami T, Nakajima J
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1222-1222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgery for secondary spontaneous pneumothorax.2010

    • Author(s)
      Nakajima J
    • Journal Title

      Curr Opin Pump Med

      Volume: 16 Pages: 376-380

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resected pleomorphic carcinoma after long-time follow-up.2010

    • Author(s)
      Takahashi T, Sano A, Yoshida Y, Fukami T, Murakawa T, Nakajima J
    • Journal Title

      Kyobu Geka

      Volume: 63 Pages: 542-545

    • NAID

      40017190521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary metastasis : rationale for local treatments and techniques.2010

    • Author(s)
      Nakajima J
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: 58 Pages: 445-451

    • NAID

      10026696085

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of lobe-selective bronchial blockade against airway bleeding.2010

    • Author(s)
      Murakawa T, Ito N, Fukami T, Nakajima J, Takamoto S
    • Journal Title

      Asian Cardiovasc Thorac Ann

      Volume: 18 Pages: 483-485

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resection of solitary pulmonary lesion is beneficial to patients with a history of malignancy.2010

    • Author(s)
      Sakamoto M, Murakawa T, Kitano K, Murayama T, Tsuchiya T, Nakajima J
    • Journal Title

      Ann Thorac Surg

      Volume: 90 Pages: 1766-1771

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨肉腫治療後二次癌として発 症した 17 歳の原発性肺癌

    • Author(s)
      此枝千尋、川島光明、佐野厚、村川知弘、 中島淳
    • Journal Title

      胸部外科

      Volume: 65巻13号 Pages: 1127-1130

    • NAID

      40019497437

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 移植気道の線維化における線 維芽細胞の起源:GFP マウスを用いた同 所性気管移植モデルでの検討.2013

    • Author(s)
      此枝千尋
    • Organizer
      第30回日本呼吸器外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Origin of Fibroblasts in Rejected Airway: Experiment with Orthotopic Tracheal Allotransplantation Model Using Transgenic GFP Mice.2013

    • Author(s)
      此枝千尋
    • Organizer
      The International Society For Heart and Lung Transplantation 33rd Annual Meeting and Scientific Sessions.
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2013-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 上皮間葉移行に着目したマウ ス気管移植の組織学的検討2013

    • Author(s)
      此枝千尋
    • Organizer
      第29回日本肺および心肺移植研究会.
    • Place of Presentation
      千葉
    • Year and Date
      2013-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 造血幹細胞移植後の閉塞性細 気管支炎に対する脳死肺移植症例の検討2013

    • Author(s)
      長山和弘
    • Organizer
      第29回日本肺および心肺移植研究会
    • Place of Presentation
      千葉
    • Year and Date
      2013-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Origin of Fibroblasts in Rejected Airway: Experiment with Orthotopic Tracheal Allotransplantation Model Using Transgenic GFP Mice.2013

    • Author(s)
      此枝千尋
    • Organizer
      The International Society For Heart and Lung Transplantation 33rd Annual Meeting and Scientific Sessions.
    • Place of Presentation
      モントリオール(カナダ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上皮間葉移行に着目したマウス気管移植の組織学的検討.2013

    • Author(s)
      此枝千尋
    • Organizer
      第29回日本肺および心肺移植研究会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 移植気道の線維化における線維芽細胞の起源:GFPマウスを用いた同所性気管移植モデルでの検討.2013

    • Author(s)
      此枝千尋
    • Organizer
      第30回日本呼吸器外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上皮間葉移行に着目したマウス気管移植の組織学的検討.2012

    • Author(s)
      此枝千尋
    • Organizer
      第48回日本移植学会総会.
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 造血幹細胞移植後の閉塞性細 気管支炎に対する脳死肺移植症例の検討.2012

    • Author(s)
      長山和弘
    • Organizer
      第48回日本移植学会総会.
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Epithelial to MesenchymalTransitionain Murine TrachealAllotransplantation:An Immunohistochemical Observation.2012

    • Author(s)
      此枝千尋
    • Organizer
      24th International Congress of TheTransplantation Society
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳死肺葉移植におけるドナー・レシピエントの全肺気量比と術後早期成績2012

    • Author(s)
      佐野厚
    • Organizer
      第28回日本肺および心肺移植研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳死肺葉移植におけるドナー・レシピエントの全肺気量比と術後早期成績2012

    • Author(s)
      佐野厚、長山和弘、村川知弘、中島淳、Peter Jaksh, Victoria Augustin, Clemens Aigner, Jose Matilla, Gyorgy Lang, Shahrokh Taghavi, Walter Klepetko
    • Organizer
      第28回日本肺および心肺移植研究会
    • Place of Presentation
      東北大学加齢医学研究所
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epithelial to Mesenchymal Transition in Murine Tracheal Allotransplantation:An Immunohistochemical Observation.2012

    • Author(s)
      此枝千尋
    • Organizer
      24th International Congress of The Transplantation Society.
    • Place of Presentation
      ベルリン(ドイツ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上皮間葉移行に着目したマウス気管移植の組織学的検討.2012

    • Author(s)
      此枝千尋
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] cN0、cN1と過小評価された非小細胞肺癌手術例の臨床病理学的特性2011

    • Author(s)
      井上雄太, 新井絢也, 此枝千尋, 北野健太郎, 坂本未紀, 佐野厚, 村川知弘, 中島淳
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 結腸・直腸癌肺転移に対する自己γδT細胞による術後補助免疫療法2011

    • Author(s)
      中島淳, 村川知弘, 長山和弘, 佐野厚, 吉田幸弘, 北野健太郎, 井上雄太, 此枝千尋, 松下博和, 垣見和宏
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 気管膜様部穿孔の治療における有茎肋間筋弁充填の有用性2010

    • Author(s)
      村川知弘、北野健太郎、坂本未紀、佐野厚、吉田幸弘、深見武史、中島淳
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非小細胞肺癌手術例における血清CEA値の意義2010

    • Author(s)
      吉田幸弘、高橋剛史、北野健太郎、坂本未紀、佐野厚、深見武史、村川知弘、太田聡、大津洋、中島淳
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 術中胸腔内洗浄液細胞診(PLC)に関する検討2010

    • Author(s)
      深見武史、此枝千尋、北野健太郎、坂本未紀、佐野厚、吉田幸弘、村川知弘、中島淳
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原発性肺癌に合併したGGO症例の臨床的検討2010

    • Author(s)
      此枝千尋、杉浦未紀、佐野厚、吉田幸弘、深見武史、村川知弘、中島淳
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Book] Annual Review呼吸器20122012

    • Author(s)
      [編集者]永井厚志, 巽浩一郎, 桑野和善, 高橋和久[著者]星野勇馬, 星野友昭, 中川原寛子, 西山守, 瀬戸口靖弘, 原弘道, 荒屋潤, 桑野和善, 高橋史行, 佐藤匡, 高橋和久, 礒濱洋一郎, 舘田一博, 石井良和, 柳重久, 三好かほり, 坪内拡伸, 中里雅光, 長瀬隆英, 海老名雅仁, 越久仁敬, 冨田桂公, 東田有智, 山口佳寿博, 谷田部恭, 十合晋作, 石井健男, 滝澤始, 後藤明輝, 李治平, 深山正久, 佐藤徹, 遠藤千顕, 近藤丘, 黒澤一, 大石淳一, 木村英晴, 西尾和人, 渡辺雅人, 田村仁樹, 石井晴之, 長谷川直樹, 渡辺裕一, 横江琢也, 足立満, 南方良章, 一ノ瀬正和, 山田芳嗣, 町田健太朗, 東元一晃, 井上博雅, 安藤克利, 瀬山邦明, 坂巻文雄, 権寧博, 小林朋子, 橋本修, 宇留賀公紀, 岸一馬, 内藤陽一, 川名明彦, 酒井洋, 更科俊洋, 松原広己, 中島淳
    • Total Pages
      270
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ctstokyo.umin.ne.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ctstokyo.umin.ne.ip/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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