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Evaluation and therapeutic application of lymphangiogenesis using animal model with lymph node metastasis of lung neoplasm

Research Project

Project/Area Number 22591561
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Toyama

Principal Investigator

DOKI Yoshinori  富山大学, 大学病院, 講師 (90303221)

Co-Investigator(Kenkyū-buntansha) NAGURA Saori  富山大学, 大学病院, 助教 (90401843)
KOIZUMI Keiichi  富山大学, 和漢医薬学研究所, 准教授 (10334715)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsがん転移 / リンパ管新生 / 腫瘍外科学 / 転移抑制 / eNOS / カルバイン / リンパ管新生阻害剤 / 肺がん / リンパ節転移 / 分子標的治療
Research Abstract

We have explored seeds that played the role of lymphangiogenetic inhibitor and evaluated 80 series of agents in the library. As a result, Shikonin had a strong inhibitory effect to lymphangiogenesis, and this affection was introduced by increasing of adhesion to some extracellular matrix, and is not by migration of lymphatic endocell. On the other hand, Deoxyshikonin which is a derivative from Shikonin, made an opposite reaction to increase an angiogenesis of lymphatic vessels.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation2012

    • Author(s)
      Prangsaengtong O
    • Journal Title

      Hum Cell

      Volume: Feb.8(Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 冠動脈ー肺動脈瘻を有する胸腺腫に対する1手術例2012

    • Author(s)
      土岐善紀、仙田一貴、本間崇浩
    • Organizer
      29回日本呼吸器外科学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 術後の有瘻生膿胸に対する二期的根治術(開窓後の大網充填術)2012

    • Author(s)
      土岐善紀、仙田一貴、本間崇浩
    • Organizer
      29回日本呼吸器外科学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Complete VATS Lobectomy with Subxiphoid Route2011

    • Author(s)
      Y.Doki, K.Senda, T.Hommma
    • Organizer
      14th World Conference of Lung Cancer
    • Place of Presentation
      Amsterdam, Nederland
    • Year and Date
      2011-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 小プレートを用いた胸骨吊り上げ法による鏡視下胸腺摘出術2011

    • Author(s)
      土岐善紀、仙田一貴、本間崇浩
    • Organizer
      28回日本呼吸器外科学会総会
    • Place of Presentation
      別府
    • Year and Date
      2011-05-13
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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