Evaluation and therapeutic application of lymphangiogenesis using animal model with lymph node metastasis of lung neoplasm
| Project/Area Number |
22591561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGURA Saori 富山大学, 大学病院, 助教 (90401843)
KOIZUMI Keiichi 富山大学, 和漢医薬学研究所, 准教授 (10334715)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | がん転移 / リンパ管新生 / 腫瘍外科学 / 転移抑制 / eNOS / カルバイン / リンパ管新生阻害剤 / 肺がん / リンパ節転移 / 分子標的治療 |
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| Research Abstract |
We have explored seeds that played the role of lymphangiogenetic inhibitor and evaluated 80 series of agents in the library. As a result, Shikonin had a strong inhibitory effect to lymphangiogenesis, and this affection was introduced by increasing of adhesion to some extracellular matrix, and is not by migration of lymphatic endocell. On the other hand, Deoxyshikonin which is a derivative from Shikonin, made an opposite reaction to increase an angiogenesis of lymphatic vessels.
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Report
(4 results)
Research Products
(5 results)
