Development of the new therapeutic approach for malignant pleural mesothelioma by the elucidation of aberrant microRNA expression
Project/Area Number |
22591566
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Shinichiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00190827)
TSUKUDA Kazunori 岡山大学, 岡山大学病院, 講師 (20346430)
ASANO Hiroaki 岡山大学, 岡山大学病院, 助教 (70534775)
SOH Junichi 岡山大学, 岡山大学病院, 助教 (90559890)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 胸部悪性腫瘍 / 分子腫瘍学 / マイクロRNA / 悪性胸膜中皮腫 / miR-34b/c / 悪性中皮腫 |
Research Abstract |
We detected that miR-34b/c was repressed by methylation in about 85% of malignant mesothelioma. Induction of miR-34b/c into the mesothelioma cell line resulted in the inhibition of the invasiveness and the induction of apoptosis. The in vivo analysis revealed that miR-34b/c had strong antitumor effect. Besides, miR-34b/c enhanced radiosensitivity of the mesothelioma cell line and the repression miR-34b/c caused the increased cell proliferation in human mesotheial cells.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells2013
Author(s)
Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Yamamoto H, Asano H, Otsuki T, Miyoshi S
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Journal Title
Oncol Rep
Volume: 29(6)
Issue: 6
Pages: 2169-74
DOI
Related Report
Peer Reviewed
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[Journal Article] MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells2012
Author(s)
Maki Y, Asano H, Toyooka S, Soh J, Kubo T, Katsui K, Ueno T, Shien K, Muraoka T, Tanaka N, Yamamoto H, Tsukuda K, Kishimoto T, Kanazawa S, Miyoshi S
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Journal Title
Anticancer Res
Volume: 32(11)
Pages: 4871-5
URL
Related Report
Peer Reviewed
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[Journal Article] Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma2011
Author(s)
Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Ueno T, Muraoka T, Yamamoto H, Nasu Y, Kishimoto T, Pass HI, Matsui H, Huh NH, Miyoshi S
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Journal Title
Clin Cancer Res
Volume: 17(15)
Issue: 15
Pages: 4965-74
DOI
Related Report
Peer Reviewed
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[Presentation] Down-regulation of microRNA34 induces cell proliferation and invasion of human mesothelial cells2012
Author(s)
Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Asano H, Otsuki T, Miyoshi S
Organizer
AACR Annual Meeting 2012
Place of Presentation
Chicago, USA
Related Report
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[Presentation] The impact of adenoviral gene transfer of microRNA-34b/c on malignant pleural mesotheliomas.2011
Author(s)
Soh J, Toyooka S, Kubo T, Fukazawa T, Sakaguchi M, Ueno T, Tsukuda K, Asano H, Yamamoto H, Huh, N, Miyoshi S
Organizer
AACR Annual Meeting 2011
Place of Presentation
Orlando, USA
Year and Date
2011-04-05
Related Report
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[Presentation] MicroRNA-34b/c is significantly down-regulated by aberrant promoter methylation and forced expression of miR-34b/c enhances the radiosensitivity in malignant pleural mesothelioma cells.2011
Author(s)
Maki Y, Toyooka S, Asano H, Soh J, Tsukuda K, Muraoka T, Aokage K, Tanaka N, Ueno T, Yamane M, Oto T, Miyoshi S
Organizer
AACR Annual Meeting 2011
Place of Presentation
Orlando, USA
Year and Date
2011-04-05
Related Report
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[Presentation] Epigenetic silencing of microRNA-34b/c plays a pivotal role in the pathogenesis of malignant pleural mesothelioma2010
Author(s)
Toyooka S, Kubo T, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Nasu Y, Kishimoto T, Pass H, Matsui H, Huh NH, Miyoshi S
Organizer
The 10th International Conference of the International Mesothelioma Interest Group
Place of Presentation
京都
Year and Date
2010-09-01
Related Report
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[Presentation] Frequent silencing of tumor suppressive miR-34b/c by aberrant methylation in malignant pleural mesothelioma2010
Author(s)
Kubo T, Toyooka S, Tsukuda K, Asano H, Sakaguchi M, Soh J, Ueno T, Yamamoto H, Yamane M, Oto T, Nasu Y, Matsui H, Huh NH, Miyoshi S
Organizer
AACR Annual Meeting 2010
Place of Presentation
Washington, DC, USA
Year and Date
2010-04-19
Related Report
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