| Project/Area Number |
22591566
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Shinichiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00190827)
TSUKUDA Kazunori 岡山大学, 岡山大学病院, 講師 (20346430)
ASANO Hiroaki 岡山大学, 岡山大学病院, 助教 (70534775)
SOH Junichi 岡山大学, 岡山大学病院, 助教 (90559890)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 胸部悪性腫瘍 / 分子腫瘍学 / マイクロRNA / 悪性胸膜中皮腫 / miR-34b/c / 悪性中皮腫 |
|---|
| Research Abstract |
We detected that miR-34b/c was repressed by methylation in about 85% of malignant mesothelioma. Induction of miR-34b/c into the mesothelioma cell line resulted in the inhibition of the invasiveness and the induction of apoptosis. The in vivo analysis revealed that miR-34b/c had strong antitumor effect. Besides, miR-34b/c enhanced radiosensitivity of the mesothelioma cell line and the repression miR-34b/c caused the increased cell proliferation in human mesotheial cells.
|
