Significant role of bone marrow-derived cells in compensatory regenerative lung growth

Research Project

Project/Area Number	22591569
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Yamaguchi University
Principal Investigator	UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
Co-Investigator(Kenkyū-buntansha)	TANAKA Toshiki 山口大学, 医学部附属病院, 助教 (50457305) LI Taosheng 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50379997)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	骨髄由来細胞 / 代償性肺成長 / compensatory lung growth / bone marrow cell / pulmonary resection / AMD3100 / 肺再生
Research Abstract	Regenerative lung growth was induced by left pneumonectomy in GFP-positive bone marrow-transplanted chimeric mice. GFP-positive cells were observed 2.1-fold more frequently in the lungs of pneumonectomized mice vs. sham operated mice by immunohistochemistry (P=0.001). Pneumonectomy induced a 1.4-fold increase in the SDF-1α level in the remaining lung at seven days compared to sham operated mice (P

Report

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