The novel therapy for pulmonary emphysema which uses autologous bone marrow-derived stem cells and the slowly released bFGF gelatin microspheres.

• Project/Area Number: 22591570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kagawa University
• Principal Investigator: TARUMI Shintaro 香川大学, 医学部, 助教 (30550082)
• Co-Investigator(Kenkyū-buntansha): MATSUURA Natsumi 香川大学, 医学部附属病院, 助教 (20572853) ; GO Tetsuhiko 香川大学, 医学部付属病院, 講師 (50313656) ; YOKOMISE Hiroyasu 香川大学, 医学部, 教授 (80231728) ; GOTOH Masashi 香川大学, 医学部附属病院, 助教 (40398029) ; YOKOTA Naoya 香川大学, 医学部附属病院, 医員 (10636492) ; 井貝 仁 香川大学, 医学部附属病院, 助教 (90419507)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 肺気腫 / 骨髄由来幹細胞 / bFGF / 肺胞再生 / 間葉系幹細胞

Research Abstract

We successfully established the canine total emphysema model and cultivated autologous bone marrow-derived stem cells. We tried a novel therapy for pulmonary emphysema through the intravenous administration of the slowly released bFGF gelatin microspheres and autologous bone marrow-derived stem cells. After a month of administration, blood gas parameters were improved.

Research Products

• [Presentation] イヌ肺気腫モデルにおける bFGF 徐放ゼラチンマイクロスフェアおよび間葉系幹細胞の肺動脈内投与による肺気腫治療の試み (2010)
  • Author(s): 張 性洙、松浦 奈都美
  • Organizer: 第63回日本胸部外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-25
• [Presentation] イヌ肺気腫モデルにおけるbFGF徐放ゼラチンマイクロスフェアおよび間葉系幹細胞の肺動脈内投与による肺気腫治療の試み (2010)
  • Author(s): 張性洙
  • Organizer: 第63回日本胸部外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-10-25