| Project/Area Number |
22591571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEHARA Yoshihiko 九州大学, 医学研究院, 教授 (80165662)
岡本 龍郎 九州大学, 大学病院, 助教 (80568626)
TAKENOYAMA Mitsuhiro 九州大学, 医学研究院, 助教 (10309966)
矢野 篤次郎 九州大学, 医学研究院, 准教授 (80304781)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 呼吸器外科学 / EMT関連遺伝子 / 非小細胞肺癌 / Activin / Podoplanin / PAI-1 / E-cadherin / Sip-1 |
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| Research Abstract |
Twist was significantly correlated with both pathological T factor and pleural invasionin squamous cell lung carcinoma. Moreover mesenchymal markers such as activin, podoplanin and PAI-1 were significantly associated with pathological T factor. Especially, both activin and PAI-1 were related with pleural invasion. N-cadherin was significantly correlated with intratumoral lymphatic invasion.
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