The strategic proteome analysis for the development of early diagnosis and therapeutic target of primary lung adenocarcinoma

• Project/Area Number: 22591573
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka City University
• Principal Investigator: NISHIYAMA Noritoshi 大阪市立大学, 大学院・医学研究科, 准教授 (90438226)
• Co-Investigator(Kenkyū-buntansha): KAKEHASHI Anna 大阪市立大学, 大学院・医学研究科, 助教 (60382222)
• Co-Investigator(Renkei-kenkyūsha): WANIBUCHI Hideki 大阪市立大学, 大学院・医学研究科, 教授 (90220970)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 呼吸器外科学 / プロテオーム / 癌 / トランスレーショナルリサーチ

Research Abstract

The comprehensive proteome analysis with frozen sample of lung adenocarcinoma tissue and adjacent normal tissue identified anterior gradient protein 2 homolog (AGR2) as a candidate protein for potential biomarker. Immunohistochemical staining showed that

Research Products

• [Journal Article] AGR2 as a potential biomarker of human lung adenocarcinoma (2012)
  • Author(s): Chung Kyukwang, Nishiyama Noritoshi, Wanibuchi Hideki, Kakehashi Anna, et al
  • Journal Title: Osaka City Med. J Volume: Vol. 58 Pages: 13-24
  • NAID: 110009418526
• [Journal Article] Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma (2012)
  • Author(s): Chung Kyukwang, Nishiyama Noritoshi, Wanibuchi Hideki, Kakehashi Anna, et al
  • Journal Title: Cancer Biomarkers Volume: 10(2) Pages: 101-107
• [Journal Article] AGR2 as a potential biomarker of human lung adenocarcinoma. (2012)
  • Author(s): Kyukwang Chung
  • Journal Title: Osaka city medical journal Volume: 58 Pages: 13-24
• [Presentation] 肺腺癌の早期発見や根治術後の予後と相関する新しい腫瘍マーカーとしての術前血清 AGR2 値の意義 (2011)
  • Author(s): 丁 奎光
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-10
• [Presentation] AGR2 as a novel useful biomarker of human lung adenocarcinoma (2011)
  • Author(s): Chung Kyukwang
  • Organizer: 14th World conference on Lung Cancer
  • Place of Presentation: Amsterdam RAI Convention CentreThe Netherlands
  • Year and Date: 2011-07-05
• [Presentation] AGR2 as a novel useful biomarker of human lung adenocarcinoma (2011)
  • Author(s): 丁奎光
  • Organizer: IASLC 14th World conference on lung cancer
  • Place of Presentation: msterdam Rai, The Netherland
  • Year and Date: 2011-07-05
• [Presentation] Q-star Elite LC-MS/MS を用いたヒト肺腺癌におけるプロテオーム解析 (2011)
  • Author(s): 小松 弘明
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] AGR2 as a novel useful biomarker of human lung adenocarcnioma (2010)
  • Author(s): 丁奎光
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] AGR2 as a novel useful biomarker of human lung adenocarcinoma (2010)
  • Author(s): 丁 奎光
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] The proteome analysis of lung adenocarcinoma (2010)
  • Author(s): Chung Kyukwang
  • Organizer: American Association for Cancer Research 101st annual meeting 2010
  • Place of Presentation: Walter E. Washington convention centerWashington, D.C.United States of America
  • Year and Date: 2010-04-21
• [Presentation] The proteome analysis of human lung adenocarcinoma (2010)
  • Author(s): 丁奎光
  • Organizer: American Association for Cancer research
  • Place of Presentation: Washington Convention Center, Washington, D.C
  • Year and Date: 2010-04-21