The molecular mechanism underlying neuronal stress response in acute ischemic stroke

• Project/Area Number: 22591578
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Chiba University
• Principal Investigator: YAMAGUCHI Atsushi 千葉大学, 大学院・医学研究院, 准教授 (00314336)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳梗塞 / MKP-1 / JNK / 脳血管障害

Research Abstract

MAP kinase phosphatase 1 (MKP-1) is an archetypal member of the dual-specificity protein phosphatase (DUSP) family, which inactivates JNK through dephosphorylation. Our findings indicate that over-expression of MKP-1 could suppress neuronal death through regulating JNK signaling and be a prominent neuroprotective target for the treatment of acute cerebral infarction.

Research Products

• [Journal Article] The Effect of PRMT1-Mediated Arginine Methylation on the Subcellular Localization, Stress Granules, and Detergent-Insoluble (2012)
  • Author(s): Yamaguchi A, Kitajo K
  • Journal Title: Aggregates of FUS/TLS PLoS One Volume: 7(11) Issue: 11 Pages: e49267-e49267
  • DOI: 10.1371/journal.pone.0049267
  • Peer Reviewed
• [Journal Article] Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling inhypoxia/re-oxygenation (2012)
  • Author(s): Koga S, Kojima S, Kishimoto T, Kuwabara S, Yamaguchi A
  • Journal Title: Brain Res Volume: 1436 Pages: 137-46
  • DOI: 10.1016/j.brainres.2011.12.004
  • Peer Reviewed
• [Journal Article] NGF and pain (2011)
  • Author(s): 山口淳
  • Journal Title: Drug Delivery System Volume: 26 Issue: 5 Pages: 457-460
  • DOI: 10.2745/dds.26.457
  • NAID: 40019043228
  • ISSN: 0913-5006, 1881-2732
• [Journal Article] The role of S6 Kinase and serotonin in maintaining nutrient balance in D. melanogaster. (2010)
  • Author(s): Vargas M, Yamaguchi A, Luo N, Kapahi P.
  • Journal Title: Current Biology Volume: 20(11) Issue: 11 Pages: 1006-11
  • DOI: 10.1016/j.cub.2010.04.009
  • Peer Reviewed
• [Journal Article] A.Temperature dependence rigidity of non-taxol stabilized single microtubules (2010)
  • Author(s): Kawaguchi K, Yamaguchi
  • Journal Title: Biochem Biophys Res Commun Volume: 402(1) Issue: 1 Pages: 66-9
  • DOI: 10.1016/j.bbrc.2010.09.112
  • Peer Reviewed
• [Journal Article] Temperature dependence rigidity of non-taxol stabilized single microtubules (2010)
  • Author(s): Kenji Kawaguchi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 402 Pages: 66-69
  • Peer Reviewed
• [Presentation] Protective effects of MKP-1 on hypoxia/reoxygenation-induced neuronal death (2012)
  • Author(s): S. KOGA, S. KOJIMA, T.KISHIMOTO, S. KUWABARA, A. YAMAGUCHI
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orlens, USA.
  • Year and Date: 2012-10-13
• [Presentation] Identification of a novel binding partner for FUS/TLS (2011)
  • Author(s): 藤井 早紀子、 宮地 秀明、古賀 俊輔、 北城 敬子、山口 淳
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] 家族性ALS原因遺伝子FUS/TLSの新規結合因子の同定 (2011)
  • Author(s): 山口淳
  • Organizer: 第34回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] 「低酸素低グルコース刺激による神経細胞 死における MKP-1 の機能解析A crucial role of map kinase phosphatase-1 (MKP-1) in neuronal death in oxygen glucose deprivation」(演題番号 : P1-q06) (2010)
  • Author(s): 古賀 俊輔, 小島 俊輔, 岸本 充, 山口 淳,桑原 聡
  • Organizer: 第33回日本神経科学大会/第53回日本神経化学会大会/第20回日本神経回路学会大会 合 同大会(Neuro2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 低酸素低グルコース刺激による神経細胞死におけるMKP-1の機能解析 (2010)
  • Author(s): 古賀俊輔, 小島俊輔, 岸本充, 山口淳、桑原聡
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(国際会議場・国際展示場)
  • Year and Date: 2010-09-02
• [Presentation] 脳梗塞における MKP-1 の機能解析 (2010)
  • Author(s): 古賀 俊輔, 山口 淳
  • Organizer: Chiba neuroscience meeting
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-24
• [Presentation] 脳梗塞急性期におけるMKP-1の機能解析 (2010)
  • Author(s): 古賀俊輔, 山口淳
  • Organizer: Chiba neuroscience meeting
  • Place of Presentation: 三井ガーデンホテル千葉
  • Year and Date: 2010-07-24
• [Presentation] Protective effects of MKP-1 on hypoxia/reoxygenation-induced neuronal death.
  • Author(s): KOGA, S.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orlens, USA.
• [Presentation] 家族性ALS原因遺伝子FUS/TLSにおけるアルギニン・メチル化の意義
  • Author(s): 藤井早紀子
  • Organizer: 第8回 Chiba Neuroscience meeting
  • Place of Presentation: 千葉市
• [Presentation] 家族性ALS 原因遺伝子 FUS/TLSの新規治療薬の可能性
  • Author(s): 藤井早紀子
  • Organizer: 千葉 Basic and Clinical Research Conference
  • Place of Presentation: 千葉市
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/neurobio/