Development of embolic material made from polyurethane for the treatment of cerebral aneurysms.

• Project/Area Number: 22591579
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YOSHINO Yoshikazu 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70323681)
• Co-Investigator(Kenkyū-buntansha): NARIAI Tadashi 東京医科歯科大学, 医歯学総合研究科, 講師 (00228090) ; AOYAGI Masaru 東京医科歯科大学, 医歯学総合研究科, 准教授 (40134704) ; KAWANO Yoshihisa 東京医科歯科大学, 医歯学総合研究科, 助教(H22, H23) (90516296)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳血管内外科学 / 生体材料 / 脳血管内手術 / 脳血管障害

Research Abstract

We coordinated the foaming density of the pore structure of polyurethane to enable to insert them into the microcatheter. We also customized this in filamentous form and put the nylon thread in the center of the foam as a core wire. These modifications were enabled us to manipulate them in the microcatheter, such as insertion and attraction, and these capabilities are inherent in standard metallic coils that have been used clinically. Furthermore, we attached some small metal markers to this material and improved its visibility under X-ray fluoroscope. In the animal experiment, there was agood neointimal covering in the surface of the aneurysm inlet (neck). In histopathological examination, fibrous tissue growth into its pore structure was obvious, and it was suggested that this material adapted well to vital reaction in aneurysmal healing in vivo. On the other hand, since this material has high radiolucency, the evaluation of the packing density in the aneurysm sac could not be accurate. For the introduction of this material to the clinical neuro-interventional field, the further improvement of the delivery system was necessary.

Research Products

• [Journal Article] 血管内治療の長期成績 (2013)
  • Author(s): 吉野義一
  • Journal Title: Current Insights in Neurological Science Volume: 19-20
• [Journal Article] Clinical characteristics andsurgical outcomes of patients with aneurysmal subarachnoid hemorrhage and acute subdural hematoma undergoing decompressive craniectomy (2011)
  • Author(s): Otani N,Takasato Y, Masaoka H, Hayakawa T, Yoshino Y, Yatsushige H, Miyawaki H, Sumiyoshi K, Sugawara T, Chikashi A,Takeuchi S, Suzuki G
  • Journal Title: World Neurosurg Volume: 75(1) Issue: 1 Pages: 73-7
  • DOI: 10.1016/j.wneu.2010.10.021
  • Peer Reviewed
• [Journal Article] Clinical characteristics and surgical outcomes of patients with aneurysmal subarachnoid hemorrhage and acute subdural hematoma undergoing decompressive craniectomy (2011)
  • Author(s): 吉野義一
  • Journal Title: World Neurosurgery Volume: 75(1) Pages: 73-77
  • Peer Reviewed
• [Journal Article] Hemorrhagic encephalitis associated with Epstein-Barr virus infection (2010)
  • Author(s): Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
  • Journal Title: J Clin Neurosci Volume: 17(1) Issue: 1 Pages: 153-4
  • DOI: 10.1016/j.jocn.2009.03.043
  • Peer Reviewed
• [Journal Article] Prognosis for severe traumaticbrain injury patients treated with bilateral decompressive craniectomy (2010)
  • Author(s): Yatsushige H, Takasato Y, Masaoka H, Hayakawa T,Otani N, Yoshino Y, Sumiyoshi K,Sugawara T, Miyawaki H, Aoyagi C, Takeuchi S, Suzuki G
  • Journal Title: Acta NeurochirSuppl. Volume: 106 Issue: 8 Pages: 265-70
  • DOI: 10.1007/s00701-002-0948-z
• [Journal Article] Surgical outcome following a decompressive craniectomy for acute epidural hematoma patients presenting with associated massive brain swelling (2010)
  • Author(s): Otani N, Takasato Y, Masaoka H, Hayakawa T, Yoshino Y, Yatsushige H, Miyawaki H, Sumiyoshi K, Sugawara T, Chikashi A, Takeuchi S, Suzuki G
  • Journal Title: Acta Neurochir Suppl Volume: 106 Pages: 261-4
  • DOI: 10.1007/978-3-211-98811-4_49
  • ISBN: 9783211987582, 9783211988114
• [Journal Article] Significance of monitoring theinitial intracranial pressure on hematoma irrigation with trephination therapy foracute subdural hematomas in critical conditions (2010)
  • Author(s): Otani N, Takasato Y, Masaoka H, Hayakawa T, Yoshino Y, Yatsushige H, Miyawaki H, Sumiyoshi K, Sugawara T, Chikashi A, Takeuchi S, Suzuki G
  • Journal Title: Acta Neurochir Suppl Volume: 106 Pages: 257-60
  • DOI: 10.1007/978-3-211-98811-4_48
  • ISBN: 9783211987582, 9783211988114
• [Journal Article] Progressive subdural hematomasafter epidural blood patch for spontaneous intracranial hypotension (2010)
  • Author(s): Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H,Sugawara T
  • Journal Title: J Anesth. Volume: 24(2) Pages: 315-6
  • Peer Reviewed
• [Journal Article] Middle cerebral artery occlusion resulting from hypereosinophilic syndrome (2010)
  • Author(s): Takeuchi S, Takasato Y, Masaoka H,Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
  • Journal Title: J Clin Neurosci Volume: 17(3) Issue: 3 Pages: 377-8
  • DOI: 10.1016/j.jocn.2009.05.033
  • Peer Reviewed
• [Presentation] もやもや病患者における3D回転DSA統合画像の有用性 (2012)
  • Author(s): 吉野義一,成相直,東森俊樹,三木一徳,井上雅人、有村公一,青柳傑,前原健寿,田中洋次,稲次基希、上田泰弘,原祥子,根本繁
  • Organizer: 第28回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2012-11-16
• [Presentation] 若年性鼻咽頭血管線維腫に対する塞栓術 (2012)
  • Author(s): 吉野義一,根本繁,東森俊樹,三木一徳,井上雅人,青柳傑,大野喜久郎,岸本誠司,角田篤信,喜多村健
  • Organizer: 第28回日本脳神経血管内治療学会学 術 総 会
  • Place of Presentation: 仙台
  • Year and Date: 2012-11-15
• [Presentation] 若年性鼻咽頭血管線維腫に対する内視鏡を用いた直接穿刺塞栓術 (2012)
  • Author(s): 吉野義一根本繁東森俊樹三木一徳井上雅人青柳傑大野喜久郎岸本誠司角田篤信喜多村健
  • Organizer: 第19回日本神経内視鏡学会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-02
• [Presentation] もやもや病患者における3D回転DSA統合画像の臨床応用 日本脳神経外科学会 (2012)
  • Author(s): 吉野義一,成相直,東森俊樹, 三木一徳,井上雅人、有村公一,青柳傑,前原健寿,田中洋次,稲次基希、上田泰弘,原祥子,根本繁
  • Organizer: 第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-19
• [Presentation] Endovascular stent therapy for symptomatic spontaneous cervical carotid artery dissection: a report of two cases (2012)
  • Author(s): Yoshikazu Yoshino, Shigeru Nemoto,Toshiki Tomori, Kazunori Miki, MasatoInoue
  • Organizer: The 10th meeting of Asian Austrarian Federation of Endovascular and Therapeutic Neuroradiology
  • Place of Presentation: Nagoya
  • Year and Date: 2012-06-16
• [Presentation] 内科治療抵抗性の頚部内頚動脈解離に対する頚動脈ステント留置術.二症例の報告 (2012)
  • Author(s): 吉野義一,東森俊樹,三木一徳,有村公一,井上雅人,根本繁
  • Organizer: 第11回日本頸部脳血管治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-06-01
• [Presentation] もやもや病患者における3D回転DSA統合画像の有用性 (2012)
  • Author(s): 吉野義一,成相直,東森俊樹,三木一徳,井上雅人、有村公一,青柳傑,前原健寿,田中洋次,稲次基希、上田泰弘, 原祥子,根本繁
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-28
• [Presentation] 若年性鼻咽頭血管線維腫の塞術栓 (2012)
  • Author(s): 吉野義一、根本繁、東森俊樹、三木一徳、井上雅人、青柳傑、大野喜久郎、岸本誠司、角田篤信、喜多村健
  • Organizer: 第20回Intravascular Neurosurgery Winter Seminar
  • Place of Presentation: 赤倉観光ホテル
  • Year and Date: 2012-03-01
• [Presentation] Endovascular stent therapy for symptomatic spontaneous cervical carotid artery dissection: a report of two cases. (2012)
  • Author(s): Yoshikazu Yoshino
  • Organizer: The 10th meeting of Asian Austrarian Federation of Endovascular and Therapeutic Neuroradiology
  • Place of Presentation: 名古屋
• [Presentation] 若年性鼻咽頭血管線維腫に対する塞栓術 (2012)
  • Author(s): 吉野義一
  • Organizer: 第28回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 治療困難な脳動脈瘤に対するエンタープライズVRDを用いた血管内手術 (2011)
  • Author(s): 吉野義一、根本繁、三木、一徳、稲次基希、菅原貴志、河野能久、大野喜久郎
  • Organizer: 第27回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-25
• [Presentation] 頭頸部腫瘍に対する血管内治療の役割 (2011)
  • Author(s): 吉野義一、根本繁、三木一徳、岸野充浩、岸本誠司、青柳傑、大野喜久郎、角田篤信、喜多村健
  • Organizer: 第27回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-25
• [Presentation] 治療困難な脳動脈瘤に対するエンタープライズVRDを用いた血管内手術 (2011)
  • Author(s): 吉野義一
  • Organizer: 第27回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-24
• [Presentation] Endovascular revascularization of chronic near or complete occlusion ofthe internal carotid artery (2011)
  • Author(s): Nemoto S, Namba K, Yoshino Y, Shojima M
  • Organizer: (Oral) The11th congress of WFITN(国際脳神経血管内治療学会)
  • Place of Presentation: Cape Town,South Africa
  • Year and Date: 2011-11-09
• [Presentation] エンタープライズVRDを用いた脳動脈瘤の治療 (2011)
  • Author(s): 吉野義一、根本繁、三木一徳、前原健寿,成相直,青柳傑,大野喜久郎
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-13
• [Presentation] エンタープライズVRDを用いて治療した脳動脈瘤三症例の報告 (2011)
  • Author(s): 吉野義一、根本繁、三木一徳、前原健寿,小幡佳輝,神田仁,大野喜久郎
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-07-30
• [Presentation] エンタープライズVRDが有用であった適応外の二症例 (2011)
  • Author(s): 吉野義一、根本繁、三木一徳、前原健寿,小幡佳輝,神田仁,大野喜久郎
  • Organizer: 第8回脳神経血管内治療学会関東地方会
  • Place of Presentation: 日本赤十字本社ビル
  • Year and Date: 2011-06-04
• [Presentation] 血管内治療科の紹介 (2011)
  • Author(s): 吉野義一根本繁三木一徳
  • Organizer: 新御茶ノ水セミナー
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2011-05-28
• [Presentation] 治療に難渋した高齢者重症破裂large内頸動脈瘤の一例 (2011)
  • Author(s): 吉野義一、根本 繁、三木一徳
  • Organizer: 第19回 Intravascular Neurosurgery Winter Seminar
  • Place of Presentation: 赤倉観光ホテル
  • Year and Date: 2011-02-11
• [Presentation] 進行性脳梗塞で発症した脳底動脈高度狭窄症の1例 (2010)
  • Author(s): 吉野義一、根本繁
  • Organizer: 第5回Tokyo Neuro-Intervention Conference
  • Place of Presentation: 東京
  • Year and Date: 2010-12-03
• [Presentation] 出血発症椎骨動脈解離性動脈瘤の臨床的特徴 (2010)
  • Author(s): 吉野義一、青柳傑、成相直,前原健寿,田中洋次,住吉京子,河野能久,武川麻紀,小幡佳輝,佐々木正史,大野喜久郎,根本繁
  • Organizer: 第26回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 小倉
  • Year and Date: 2010-11-19
• [Presentation] 出血発症椎骨動脈解離性動脈瘤の臨床的特徴 (2010)
  • Author(s): 吉野義一,青柳傑,成相直,前原健寿,田中洋次,住吉京子,河野能久,武川麻紀,小幡佳輝,佐々木正史,大野喜久郎
  • Organizer: 第69回日本脳神経外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-29
• [Presentation] 血発症椎骨動脈解離性動脈瘤の臨床的特徴 (2010)
  • Author(s): 吉野義
  • Organizer: 第69回日本脳神経外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-29
• [Book] Current Insights inNeurological Science (2013)
  • Author(s): 吉野義一、根本繁
  • Publisher: 株式会社マッキャンヘルスケアワールドワイドジャバン、血管内手術の長期成績