Functional and histological analysis of brain microcirculation after subarachnoid hemorrhage

• Project/Area Number: 22591582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Shinshu University
• Principal Investigator: HORIUCHI Tetsuyoshi 信州大学, 医学部, 准教授 (40303466)
• Co-Investigator(Kenkyū-buntansha): HONGO Kazuhiro 信州大学, 医学部, 教授 (00135154) ; MURATA Takahiro 信州大学, 医学部附属病院, 助教 (80533322)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脳微小循環 / くも膜下出血 / カリウム / マグネシウム / レンズ核線条体動脈

Research Abstract

We investigated the effects of changing the extracellular potassium as well as magnesium concentration in rat cerebral penetrating arterioles. It was difficult to evaluate the histological change of cerebral penetrating arterioles including Virchow-Robin space. MRI perfusion images showed no remarkable alternation of local blood flow in basal ganglia after subarachnoid hemorrhage.

Research Products

• [Journal Article] Early changes in tissue perfusion after tissue plasminogen activator administration in hyperacute ischemic stroke: initial experiences with arterial spin labeling perfusion magnetic resonance imaging -two case reports- (2013)
  • Author(s): Rahman NN, Horiuchi T, Hongo K
  • Journal Title: Neurologia medico-chirurgica Volume: 53 Pages: 213-216
  • NAID: 10031151332
  • Peer Reviewed
• [Journal Article] Early Changes in Tissue Perfusion After Tissue Plasminogen Activator Administration in Hyperacute Ischemic Stroke: Initial Experiences With Arterial Spin Labeling Perfusion Magnetic Resonance Imaging -Two Case Reports- (2013)
  • Author(s): Rahman NN, Horiuchi T, Hongo K
  • Journal Title: Neurologia medico-chirurgica Volume: 53 Pages: 213-216
  • NAID: 10031151332
  • Peer Reviewed
• [Journal Article] Vasomotor response induced by change of extracellular potassium and magnesium in cerebral penetrating arterioles. (2011)
  • Author(s): Murata T, Horiuchi T, Goto T, Li Y, Hongo K
  • Journal Title: Neuroscience Research Volume: 70 Pages: 30-34
  • Peer Reviewed
• [Journal Article] Mechanism of alkalosis-induced constriction of rat cerebral penetrating arterioles. (2011)
  • Author(s): Li Y, Horiuchi T, Murata T, Hongo K
  • Journal Title: Neuroscience Research Volume: 70 Pages: 98-103
  • Peer Reviewed
• [Journal Article] Vasomotor response induced by change of extracellular potassium and magnesium in cerebral penetrating arterioles (2011)
  • Author(s): Murata T, Horiuchi T, Goto T, Li Y, Hongo K
  • Journal Title: Neuroscience Research Volume: 70 Issue: 1 Pages: 30-34
  • DOI: 10.1016/j.neures.2011.01.017
  • Peer Reviewed
• [Journal Article] Mechanism of alkalosis-induced constriction of rat cerebral penetrating arterioles (2011)
  • Author(s): Li Y, Horiuchi T, Murata T, Hongo K
  • Journal Title: Neuroscience Research Volume: 70 Issue: 1 Pages: 98-103
  • DOI: 10.1016/j.neures.2011.01.009
  • Peer Reviewed
• [Presentation] 脳卒中診療における 3D Arterial Spin Labeling (3D-ASL) の有用性 (2012)
  • Author(s): 瀬口達 也、 堀内哲吉 、 Nunung Nur Rahmah
  • Organizer: 第40回日本救急医学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-15
• [Presentation] Aanalysis of vasodilation induced by increased extracellular magnesium concentration in cerebral penetratingarterioles. (2012)
  • Author(s): Murata T, Dietrich HH, Horiuchi T, Hongo K, Dacey RG Jr.
  • Organizer: 42nd Annual Meeting of Society for Neuroscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-16
• [Presentation] 脳細動脈における細胞外マグネシウム濃度増加による血管拡張 (2012)
  • Author(s): 村田貴弘、Dietrich HH、堀内哲吉、本郷一博、Dacey RG Jr.
  • Organizer: 第28回スパスム・シンポジウム STROKE2012
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-26
• [Presentation] Aanalysis of vasodilation induced by increased extracellular magnesium concentration in cerebral penetrating arterioles. (2012)
  • Author(s): Murata T, Dietrich HH, Horiuchi T, Hongo K, Dacey RG Jr.
  • Organizer: 42nd Annual Meeting of Society for Nueroscience,
  • Place of Presentation: New Orleans, USA
• [Presentation] 脳卒中診療における 3D Arterial Spin Labeling (3D-ASL) の有用性. (2012)
  • Author(s): 瀬口達也、堀内哲吉、Nunung Nur Rahmah
  • Organizer: 第40回日本救急医学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 脳細動脈における細胞外マグネシウム濃度増加による血管拡張. (2012)
  • Author(s): 村田貴弘、Hans H. Dietrich、堀内哲吉、本郷一博、Ralph G. Dacey Jr.
  • Organizer: 第28回スパスム・シンポジウム STROKE2012
  • Place of Presentation: 福岡
• [Presentation] MR 非造影灌流画像を用いた脳血流検査の有用性 (2011)
  • Author(s): 堀内 哲吉
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 東京
• [Presentation] MR非造影灌流画像を用いた脳血流検査の有用性 (2011)
  • Author(s): 堀内哲吉、ラーマーヌヌン、瀬口達也、本郷一博
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 東京
• [Presentation] 摘出ラットレンズ核線条体動脈におけるマグネシウムならびにカリウムによる血管反応性の解析 (2010)
  • Author(s): 堀内 哲吉
  • Organizer: 第22回 日本 脳循 環代謝 学会総 会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-27
• [Presentation] 摘出ラットレンズ核線条体動脈におけるマグネシウムならびにカリウムによそ血管反応性の解析 (2010)
  • Author(s): 堀内哲吉
  • Organizer: 第22回日本脳循環代謝学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-27