The influence of genetic polymorphism on preoperative platelet function testing in patients undergoing Carotid Artery Stenting
| Project/Area Number |
22591591
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIRA Jun-ichi 九州大学, 大学院・医学研究院, 教授 (40183305)
OHOYAGI Yasumasa 九州大学, 大学院・医学研究院, 教授 (30301336)
FURUTA Kounoske 九州大学, 大学病院, 特任助教 (60546571)
鳥居 孝子 九州大学, 大学病院, 学術研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 頚動脈ステント留置術 / 抗血小板薬不応性 / 遺伝子多型 / クロピドグレル / CYP2C19 / Verify now / 血小板不応症 / ＣＹＰ２Ｃ１９ / ＰＯＮ－１ / 脳血管内治療 / 頸動脈ステント留置術 / 脳動脈コイル塞栓術 / verify now |
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| Research Abstract |
The proportion of the CYP2C19 loss-of-function alleles (*2,*3) was relatively high and CYP2C19 gain-of-function allele (*17) was rare in the Japanese patients undergoingcarotid artery stenting. The proportion of non-responder of clopidogrel is higher in patients with CYP2C19 LOF allele. There was no significant association between non-responder of clopidogrel and periprocedural complication.
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Report
(4 results)
Research Products
(14 results)
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[Presentation]2011
Author(s)
松本省二ほか
Organizer
第27回日本脳神経血管内治療学会総会
Place of Presentation
幕張メッセ(千葉)
Year and Date
2011-11-24
Related Report
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