| Project/Area Number |
22591592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUYAMA Kazuhiko 長崎大学, 大学院・医歯薬学総合研究科, 客員研究員 (60236057)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Akifumi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (10198327)
SO Gohei 長崎大学, 大学病院, 医員 (80530427)
BABA Shiro 長崎大学, 大学病院, 医員 (30530430)
SAITO Kuniaki 京都大学, 大学院・医医学系研究科, 教授 (80262765)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳血管障害学 / ＩＤＯ / 頸動脈プラーク / 頸動脈内膜剥離術 / ＭＲＩ / IDO / MRI |
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| Research Abstract |
We studied clinical implication of indoleamine-2,3-dioxygenese (IDO), a tryptophan metabolite, for plaque instability in patients undergoing endarterectomy for atherosclerotic carotid stenosis. Although radiological examination such as high-resolution MR plaque imaging could detect plaque instability, any of serological markers has not yet been established. Relevance of local existence of IDO and characteristics of carotid plaque is immuno- histochemically under investigation.
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