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The role of gangliosides for neuroregeneration in ischemic stroke

Research Project

Project/Area Number 22591593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSapporo Medical University

Principal Investigator

MIKAMI Takeshi  札幌医科大学, 医学部, 講師 (30372816)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳神経疾患 / 糖脂質 / ガングリオシド / 脳虚血 / 神経再生 / 脳梗塞 / もやもや病 / 脳動静脈奇形 / phosphodiesterase / CT / MRI / NMR / 間葉系幹細胞移植
Research Abstract

High performance liquid chromatography (HPLC) was performed to detect the difference of glycolipid between the normal and the infarcted brains, however, the sensitivity was not enough to detect the differences. The microarray analysis indidated that the expression of phosphodiesterase 10A (PDE10A) was high in the infarted brain compared to the normal brain. We performed immunohistochemical analysis with anti-PDE10A antibody. The results indicated that the PDE10A is associated with neural regeneration. Thus, we will perform furth er studies forneuroregeneration with these results.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model2013

    • Author(s)
      Suzuki J, Sasaki M, Harada K, BandoM, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O
    • Journal Title

      Brain Res

      Volume: 1497C Pages: 15-22

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Moyamoya Disease Using Multidetector Row Computed Tomography2012

    • Author(s)
      Sugino T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub Issue: 5 Pages: 644-649

    • DOI

      10.1016/j.jstrokecerebrovasdis.2012.01.014

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 甲状腺機能亢進症に合併した類もやもや病2012

    • Author(s)
      三上毅
    • Journal Title

      脳卒中

      Volume: 34(2) Pages: 82-88

    • NAID

      130004543239

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presurgical planning for arteriovenous malformations using multidetector row CT2012

    • Author(s)
      Mikami T
    • Journal Title

      Neurosurg Rev

      Volume: 35 Issue: 3 Pages: 393-400

    • DOI

      10.1007/s10143-012-0383-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial Spin-Labeling Magnetic Resonance Imaging after Revascularization of Moyamoya Disease2012

    • Author(s)
      Sugino T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub Issue: 6 Pages: 811-816

    • DOI

      10.1016/j.jstrokecerebrovasdis.2012.05.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of Moyamoya Disease on Magnetic Resonance Imaging: Are Flow Voids in the Basal Ganglia an Essential Criterion for Definitive Diagnosis?2012

    • Author(s)
      Mikami T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub Issue: 6 Pages: 862-868

    • DOI

      10.1016/j.jstrokecerebrovasdis.2012.07.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bumping phenomenon during continuous coagulation with bipolar forceps2012

    • Author(s)
      Mikami T
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 731-5

    • NAID

      10030873403

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] もやもや病におけるもやもや血管の増勢と内膜肥厚2013

    • Author(s)
      三上毅
    • Organizer
      Stroke 2013
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] もやもや病における大脳基底核部flow voidと脳槽flow voidの診断的意義2012

    • Author(s)
      三上毅
    • Organizer
      Stroke 2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diagnosis of moyamoya disease on MRI; Flow voids in the basal ganglia are an essential criterion for definitive diagnosis?2012

    • Author(s)
      Mikami T
    • Organizer
      Asia Pacific Stroke Conference 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Area Detector CTによるperfusion CTの使用経験2011

    • Author(s)
      三上毅、飯星智史、杉野寿哉、三國信啓
    • Organizer
      第23回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Multidetector Row CTによるもやもや病の診断2011

    • Author(s)
      杉野寿哉、三上毅、飯星智史、小柳泉、宝金清博
    • Organizer
      Stroke 2011
    • Place of Presentation
      京都
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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