The role of gangliosides for neuroregeneration in ischemic stroke
| Project/Area Number |
22591593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳神経疾患 / 糖脂質 / ガングリオシド / 脳虚血 / 神経再生 / 脳梗塞 / もやもや病 / 脳動静脈奇形 / phosphodiesterase / CT / MRI / NMR / 間葉系幹細胞移植 |
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| Research Abstract |
High performance liquid chromatography (HPLC) was performed to detect the difference of glycolipid between the normal and the infarcted brains, however, the sensitivity was not enough to detect the differences. The microarray analysis indidated that the expression of phosphodiesterase 10A (PDE10A) was high in the infarted brain compared to the normal brain. We performed immunohistochemical analysis with anti-PDE10A antibody. The results indicated that the PDE10A is associated with neural regeneration. Thus, we will perform furth er studies forneuroregeneration with these results.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model2013
Author(s)
Suzuki J, Sasaki M, Harada K, BandoM, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O
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Journal Title
Brain Res
Volume: 1497C
Pages: 15-22
Related Report
Peer Reviewed
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