Cerebral aneurysm rupture risk estimation of with artery thickness.

• Project/Area Number: 22591599
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Waseda University (2012); Tokyo University of Technology (2010-2011)
• Principal Investigator: YI Qian 早稲田大学, 理工総合研究所, 客員教授 (80389147)
• Co-Investigator(Kenkyū-buntansha): UMEZU Mitsuo 早稲田大学, 理工学部, 教授 (90132927) ; MURAYAMA Yuichi 慈恵医科大学, 脳神経学科, 教授 (00239550)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳動脈瘤 / 血流シミュレーション / 臨床データベース

Research Abstract

Anew approach using the technology of solid-liquid interaction model to estimate the risk of aneurysm rupture was performed under hemodynamic conditions. Flow energy loss in aneurysms was significantly different between ruptured-aneurysms and stable-aneurysms. The preliminary study found that greater energy loss occurred when flow passed through ruptured aneurysms, when compared to unruptured aneurysms. This new concept of energy loss may become a useful tool for the prediction of aneurysm rupture. These preliminary results indicated that EL may be a useful parameter for the quantitative estimation of the risks of rupture for aneurysms.

Research Products

• [Journal Article] The Influence of Elastic Upstream Artery Length on Fluid-Structure Interaction Modelling : A Comparative Study using Patient-Specific Cerebral Aneurysm (2013)
  • Author(s): C J Lee, Y Zhang, H Takao, Y Murayama, and Y Qian
  • Journal Title: Medical Engineering & Physics Volume: (Accept)
• [Journal Article] Analysis of Morphologic and Hemodynamic Parameters for Unruptured Posterior Communicating Artery Aneurysms with Oculomotor Nerve Palsy (2013)
  • Author(s): Ying Yu, Jinyu Xu, Xi Wu, Yongfa Wu, Che Jiang, Qinghai Huang, Yi Qian, Jianmin Liu
  • Journal Title: Am J Neuroradiol Volume: (Accepted)
• [Journal Article] A Comparison of Estimation Methods for CFD Outflow Boundary Conditions Using Patient-Specific Carotid Artery (2013)
  • Author(s): Chang-Joon Lee, Nahoko Uemiya, Shoichiro Ishihara, Yu Zhang, Yi Qian
  • Journal Title: Journal of Engineering in Medicine Volume: (Accepted)
• [Journal Article] A combination of genetic, molecular and haemodynamic risk factors contributes to the formation, enlargement and rupture of brain aneurysms (2013)
  • Author(s): S Francis, J Tu Y Qian, A Avolio
  • Journal Title: Journal of Clinical Neuroscience Volume: (Accepted)
• [Journal Article] Numerical analysis of blood flow distribution in 4-branch and 3-branch vascula r grafts (2013)
  • Author(s): C Konouraa, T Yagi, M Nakamura, K Iwasaki, Y Qian, S Okudaf, A Yoshitakeg, H Shimizu, R Yozu, M Umezu
  • Journal Title: Journal of Artificial Organs Volume: (accepted)
• [Journal Article] The Influence of Elastic Upstream Artery Length on Fluid-Structure Interaction Modelling: A Comparative Study using Patient-Specific Cerebral Aneurysm (2013)
  • Author(s): C J Lee, Y Zhang, H Takao, Y Murayama, and Y Qian
  • Journal Title: Medical Engineering & Physics Volume: in press
  • Peer Reviewed
• [Journal Article] Analysis of Morphologic and Hemodynamic Parameters for Unruptured Posterior Communicating Artery Aneurysms with Oculomotor Nerve Palsy (2013)
  • Author(s): Ying Yu, Jinyu Xu, Xi Wu, Yongfa Wu, Che Jiang, Qinghai Huang, Yi Qian, Jianmin Liu
  • Journal Title: Am J Neuroradiol, Accepted Volume: in press
  • Peer Reviewed
• [Journal Article] Comparison of Estimation Methods for CFD Outflow Boundary Conditions Using Patient-Specific Carotid Artery (2013)
  • Author(s): Chang-Joon Lee, Nahoko Uemiya, Shoichiro Ishihara, Yu Zhang, Yi Qian
  • Journal Title: Journal of Engineering in Medicine Volume: in press
  • Peer Reviewed
• [Journal Article] A comparison of the hemodynamic effects of flow diverters on wide-necked and narrow-necked cerebral aneurysms (2013)
  • Author(s): Yong-Fa Wua, Peng-Fei Yang, Jie Shen, Qing-Hai Huang, Xing Zhang, Yi Qian, Jian-Min Liu
  • Journal Title: Journal of Clinical Neuroscience Volume: in press
  • Peer Reviewed
• [Journal Article] Investigation Of Intracranial Aneurysm Hemodynamics Following Flow Diverter Stent Treatment (2013)
  • Author(s): Y Zhang, W Chong, Y Qian
  • Journal Title: Medical Engineering & Physics Volume: 35 Pages: 608-615
  • Peer Reviewed
• [Journal Article] A comparison of the hemodynamic effects of flow diverters on wide-necked and narrow-necked cerebral aneurysms (2012)
  • Author(s): Yong-Fa Wua, Peng-Fei Yang, Jie Shen, Qing-Hai Huang, Xing Zhang, Yi Qian Jian-Min Liu
  • Journal Title: Journal of Clinical Neuroscience Volume: 19(11) Pages: 1520-4
• [Journal Article] Investigation Of Intracranial Aneurysm Hemodynamics Following Flow Diverter Stent Treatment (2012)
  • Author(s): Y Zhang, W Chong, Y Qian
  • Journal Title: Medical Engineering & Physics Volume: (Accept)
• [Journal Article] Mean Arterial Pressure Required for Intracranial Bypass Grafts : An Investigation with Computational Hemodynamic Models (2012)
  • Author(s): S F Sia, Y Qian, Y Zhang, M K Morgan
  • Journal Title: Neurosurgery Volume: 71(4) Pages: 826-31
• [Journal Article] Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation (2012)
  • Author(s): H Takao, Y Murayama, S Otsuka, Y Qian, et al
  • Journal Title: Stroke Volume: 43 Pages: 1436-9
• [Journal Article] Flow Resistance Analysis of Extracranial-To-Intracranial (EC-IC) Vein Bypass (2012)
  • Author(s): Y Zhang, S F Sia, M K Morgan, Y Qian
  • Journal Title: J Biomech Volume: 45 Pages: 1400-5
• [Journal Article] Proposition of an outflow boundary approach for carotid artery stenosis CFD simulation (2012)
  • Author(s): Zhang Y, Furusawa T, Sia S F, Umezu M, and Qian Y
  • Journal Title: Computer Methods in Biomechanics and Biomedical Engineering
• [Journal Article] Mean Arterial Pressure Required for Intracranial Bypass Grafts: An Investigation with Computational Hemodynamic Models (2012)
  • Author(s): S F Sia, Y Qian, Y Zhang, M K Morgan
  • Journal Title: Neurosurgery Volume: 71(4) Pages: 826-8311
  • Peer Reviewed
• [Journal Article] Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation (2012)
  • Author(s): H Takao, Y Murayama, S Otsuka, Y Qian, et al,
  • Journal Title: Stroke Volume: 43 Pages: 1436-1439
  • Peer Reviewed
• [Journal Article] Risk Analysis of Unruptured Aneurysms Using Computed Fluid Dynamics Technology : Preliminary Results (2011)
  • Author(s): Y. Qian, H. Takao, M. Umezu and Y. Murayama
  • Journal Title: AJNR Am J Neuroradiol Volume: 32(10) Pages: 1948-55
• [Journal Article] Risk Analysis of Unruptured Aneurysms Using Computed Fluid Dynamics Technology : Preliminary Results, Nov-Dec; 32(10):1948-55, 2011 (2011)
  • Author(s): Y.Qian, H.Takao, M.Umezu, Y.Murayama
  • Journal Title: AJNR Am J Neuroradiol Volume: 32(10) Pages: 1948-55
  • Peer Reviewed
• [Journal Article] Risk analysis of unruptured aneurysm using computed fluid dynamics technology : preliminary results (2011)
  • Author(s): Qian Y, Takao H, Umezu M, Murayama Y
  • Journal Title: Am J Neuroradiol Volume: (12月予定 in-press)
  • Peer Reviewed
• [Presentation] CFD Reveals Hemodynamic Differences Between Unruptured And Ruptured Intracranial Aneurysms During Observation (2012)
  • Author(s): H Takao, Y Murayama, T Ishibashi, I Yuki, S Otsuka, T Suzuki, S Masuda, A Mohamed, Y Qian (I Sen), M Yamamoto, and T Abe
  • Organizer: Stroke
  • Place of Presentation: USA
• [Presentation] Hemodynamic Simulation for Surgical Treatment of Congenital Heart Disease (2012)
  • Author(s): Y Qian, J L Liu, and J F Liu
  • Organizer: 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012 (EMBC'12),
  • Place of Presentation: USA
• [Presentation] Estimation of an outflow boundary approach for carotid artery stenosis CFD simulation (2012)
  • Author(s): Y Qian
  • Organizer: ICS 2012
  • Place of Presentation: Madison, USA
• [Presentation] Estimation of an outflow boundary approach for carotid artery stenosis CFD simulation (2012)
  • Author(s): Yi Qian
  • Organizer: ICS 2012
  • Place of Presentation: アメリカ
• [Presentation] An Approach of Computational Hemodynamics for Cardiovascular Flow Simulation (2011)
  • Author(s): J L Liu, Y Qian T. Miyakoshi K. Itatani, K. Miyaji , M. Umezu
  • Organizer: Proceedings of ASME-JSME-KSME Joint Fluids Engineering Conference 2011 AJK2011-03057
  • Place of Presentation: 茨城
• [Presentation] Hemodynamic Features of Cerebral Aneurysms that Influence to Rupture (2011)
  • Author(s): Y Qian
  • Organizer: ESCTAIC 22nd Annual Meeting
  • Place of Presentation: Erlangen, Germany
• [Presentation] The Critical Risk Analysis for Middle Cerebral Artery (MCA) Aneurysm by hemodynamic Characteristics (2011)
  • Author(s): Y Qian, W Chong, J M Liu, Y Murayama
  • Organizer: WFINT 2011
  • Place of Presentation: Cape Town, South Africa
• [Presentation] Hemodynamic Features of Cerebral Aneurysms that Influence to Rupture (2011)
  • Author(s): Y Qian
  • Organizer: ESCTAIC 22nd Annual Meeting
  • Place of Presentation: Erlangen, Germany(招待講演)
• [Presentation] The Critical Risk Analysis for Middle Cerebral Artery (MCA) Aneurysm by hemodynamic Characteristics (2011)
  • Author(s): Y Qian, W Chong, J M Liu, Y Murayama
  • Organizer: WFINT 2011
  • Place of Presentation: Cape Town, South Africa(招待講演)
• [Presentation] An Approach of Computational Hemodynamics for Cardiovascular Flow Simulation, AJK2011-03057 (2011)
  • Author(s): J L Liu, Y Qian, T.Miyakoshi, K.Itatani, K.Miyaji, M.Umezu
  • Organizer: Proceedings of ASME-JSME-KSME Joint Fluids Engineering Conference 2011
  • Place of Presentation: 浜松,静岡県
• [Presentation] Computational Hemodynamic Analysis for TCPC Pulsatile Simulation with Considering the Influence of Respiration (2010)
  • Author(s): J L Liu, Y Qian , Q Sun, J F Liu, K Itatai , K Miyaji , and M Umezu
  • Organizer: Proceedings of the ASME 2010 Summer Bioengineering Conference (SBC2010)
  • Place of Presentation: Grande Beach Resort, Naples Florida, USA
• [Presentation] Cerebral vascular fluid-structure interaction analysis in a patient-specific ICA aneurysm, invited lecture (2010)
  • Author(s): Matsuda W, Qian Y, Umezu M, Takao H, Murayama Y, Tu J
  • Organizer: WCCM 2010
  • Place of Presentation: オーストラリア・シドニー、国際会議場
• [Presentation] Cerebral Aneurysms : Aspect Ratio and Optimal Features of Intra-aneurysmal flow and energy loss (2010)
  • Author(s): A Avolio, A Famoush, P Khalfeh, Y Qian
  • Organizer: 6th World Congress of Biomechanics
  • Place of Presentation: Singapore、国際会議場
• [Presentation] Evaluation of Brain Extracranial-to Intracranial (EC=IC) Bypass Treatments by using Computational Hemodynamic Technology (2010)
  • Author(s): S F Sia Y Qian, W Matsuda, A Avolio, M Morgan
  • Organizer: WCCM 2010
  • Place of Presentation: オーストラリア・シドニー、国際会議場
• [Presentation] From flow models to the real world Can we predict which aneurysm will rupture? (2010)
  • Author(s): Y Qian
  • Organizer: AAFITN 2010
  • Place of Presentation: オーストラリア、Melbourne,国際会議場
• [Presentation] Numerical Simulation and Hemodynamic Analysis of the Modified Blalock-Taussig Shunt
  • Author(s): J L Liu, J Sun, , JF Liu, and Y Qian
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13)
  • Place of Presentation: Osaka