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evaluation of plaque vulnerability by plasma oxidized LDL

Research Project

Project/Area Number 22591600
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKawasaki Medical School

Principal Investigator

UNO Masaaki  川崎医科大学, 医学部, 教授 (90232884)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Shunji  川崎医科大学, 医学部, 准教授 (60294675)
MATSUZAKI Kazuhito  川崎医科大学, 医学部, 講師 (90363168)
TOI Hiroyuki  川崎医科大学, 医学部, 講師 (80551960)
Co-Investigator(Renkei-kenkyūsha) MATSUURA Eiji  岡山大学, 医歯(薬)学総合研究科, 教授 (20181688)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頸動脈狭窄症 / 酸化 LDL / 頸動脈エコー / 酸化LDL / 頸動脈内膜剥離術 / 頸動脈ステント
Research Abstract

The association between oxidized low-density lipoprotein (OxLDL) and vulnerability of carotid plaque is suspected but not established. We performed this study to determine whether plasma OxLDL is useful biomarker as a vulnerability of carotid plaque. Plasma OxLDL levels were determined in 49 CEA and 47 CAS patients. However, this studydemonstrated no association between plasma OxLDL and vulnerability of carotid plaque.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (10 results) (of which Invited: 2 results) Book (4 results)

  • [Journal Article] Strokeinevolutionを呈する急性期頚動脈狭窄症に対する血行再建術2013

    • Author(s)
      兼松康久、里見淳一郎、西京子、松原俊二、宇野昌明、花岡真実、佐藤浩一、永廣信治
    • Journal Title

      脳卒中の外科

      Volume: 41巻 Pages: 1-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced carotid plaque on contrast-enhanced ultrasound is associated with plaque instability and rupture.2012

    • Author(s)
      Matsumoto N, Kimura K, Uno M, Sakai K, Sadahira Y, Nishimura H
    • Journal Title

      International Journal of stroke

      Volume: 7巻 Pages: 12-12

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 上級編-Patchan gioplastyを用いたCEA2012

    • Author(s)
      宇野昌明,頸動脈内膜剥離術
    • Journal Title

      脳神経外科速報

      Volume: 22巻 Pages: 394-403

    • Related Report
      2012 Final Research Report
  • [Journal Article] 頚動脈内膜剥離術2012

    • Author(s)
      宇野昌明
    • Journal Title

      脳外誌

      Volume: 21巻 Pages: 943-948

    • NAID

      10031131664

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頸動脈内膜剥離術:上級編-Patch angioplastyを用いたCEA-2012

    • Author(s)
      宇野昌明
    • Journal Title

      脳神経外科速報

      Volume: 22 Pages: 394-403

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 超音波検査による脳梗塞再発リスクの評価2011

    • Author(s)
      松本典子、木村和美、宇野昌明、西村広健
    • Journal Title

      脳と循環

      Volume: 16巻 Pages: 62-67

    • Related Report
      2012 Final Research Report
  • [Journal Article] Freehand technique for Putaminal Hemorrhage2011

    • Author(s)
      Yokosuka K, Uno M, et al
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 51 Pages: 543-546

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An embolic bow hunter's stroke associated with anomaly of cervical2011

    • Author(s)
      Sakamoto Y, Uno M, et al
    • Journal Title

      Neurology

      Volume: 77 Pages: 1403-1404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paraspinal arteriovenous fistula presenting with subarachnoid hemorrhage and acute progressive myelopathy. -Case report-2011

    • Author(s)
      Toi H, Matsubra S, T, Uno M, et al
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 51 Pages: 846-849

    • NAID

      10030030787

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頚動脈内膜剥離術の適応と手術手技2010

    • Author(s)
      宇野昌明、永廣信治
    • Journal Title

      脈管学

      Volume: 50巻 Pages: 303-308

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and clinical correlation of intracranial hemorrhages observed by 3-Tsesla gradient Echo T2^*-weighted images following intravenous thrombolysis with recombinant tissue plasminogen activator2010

    • Author(s)
      Harada M, Uno M, et al
    • Journal Title

      Cerebrovasc Dis

      Volume: 29 Pages: 571-575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コイル塞栓術後の脳動脈瘤手術の成績と注意点2010

    • Author(s)
      宇野昌明、戸井宏行、松原俊二, 他
    • Journal Title

      脳神経外科ジャーナル

      Volume: 19 Pages: 616-622

    • NAID

      110007686913

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頸動脈狭窄症に対する外科治療:CEAの役割2013

    • Author(s)
      宇野昌明
    • Organizer
      第42回日本脳卒中の外科
    • Place of Presentation
      東京
    • Year and Date
      2013-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者頚動脈狭窄症の血行再建術2013

    • Author(s)
      宇野昌明
    • Organizer
      第26回日本老年脳神経外科学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 頸動脈狭窄症に対する外科治療:CEAの役割。2013

    • Author(s)
      宇野昌明
    • Organizer
      第42回日本脳卒中の外科
    • Place of Presentation
      グランドプリンスホテル(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 頸動脈狭窄症に対する治療方法の選択-内科・外科の脳卒中チームとしての治療選択2012

    • Author(s)
      宇野昌明、松原俊二、木村和美、松本典子
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ステップアップの手術手技頸動脈内膜剥離術2012

    • Author(s)
      宇野昌明
    • Organizer
      第32回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] ステップアップの手術手技頸動脈内膜剥離術、2012

    • Author(s)
      宇野昌明
    • Organizer
      第32回日本脳神経外科コングレス総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 頸動脈狭窄症に対する治療方法の選択-内科・外科の脳卒中チームとしての治療選択2012

    • Author(s)
      宇野昌明
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性期CEAの適応と問題点2011

    • Author(s)
      宇野昌明
    • Organizer
      第10回日本頸部脳血管治療学会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-06-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] CEAの治療成績。-ハイリスクを除く2011

    • Author(s)
      宇野昌明
    • Organizer
      第9回日本頸部脳血管治療学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] CEAの治療成績2010

    • Author(s)
      宇野昌明
    • Organizer
      第9回日本頸部脳血管治療学会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Book] 3手術のタイミングA虚血症状出現後の手術時期。頚動脈内膜剥離術プラクティス2013

    • Author(s)
      宇野昌明
    • Publisher
      メディカ出版
    • Related Report
      2012 Final Research Report
  • [Book] 4CEA手術の実際3Eパッチの使用:使用素材と手技。頚動脈内膜剥離術プラクティス2013

    • Author(s)
      宇野昌明
    • Publisher
      メディカ出版
    • Related Report
      2012 Final Research Report
  • [Book] 頚動脈内膜剥離術プラクティス2013

    • Author(s)
      宇野昌明:
    • Total Pages
      287
    • Publisher
      メディカ出版,
    • Related Report
      2012 Annual Research Report
  • [Book] 頸部頸動脈狭窄に対する治療適応と治療法の選択はEBM・脳神経外科疾患の治療2011-20122010

    • Author(s)
      宇野昌明
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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