Enhancement of BPA uptake using preloading method in boron neutron capture therap

• Project/Area Number: 22591604
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811) ; NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284) ; MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脳腫瘍学 / 粒子線治療 / BNCT / BPA / ホウ素 / Glioblastoma / 中性子捕捉療法

Research Abstract

Intracellular boron accumulation in CHO-K1 cells was particularly increased by co-loading BPA with L-Tyr-O-Et. This increase is caused by activation of a system L amino acid exchanger between BPA and L-Tyr. We expect that this amion acid transport control will be useful for enhancing intracellular boron accumulation.

Research Products

• [Journal Article] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation (2011)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Mizumoto M, Tsuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1817-1818
  • Peer Reviewed
• [Journal Article] A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba (2011)
  • Author(s): Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1819-22
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma: A recursive partitioning analysis of BNCT patients (2011)
  • Author(s): Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A:
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1790-2
  • Peer Reviewed
• [Journal Article] Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy (2011)
  • Author(s): Matsuda M, Yamamoto T, Ishikawa E, Nakai K, Zaboronok A, Takano S, Matsumura A
  • Journal Title: Br J Radiol Volume: No 1
  • NAID: 120007137315
  • Peer Reviewed
• [Journal Article] Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy (2011)
  • Author(s): Matsuda M, Yamamoto T, et al.
  • Journal Title: Br J Radiol Volume: 84 Pages: 54-60
  • NAID: 120007137315
  • Peer Reviewed
• [Journal Article] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2011)
  • Author(s): Yamamoto T, Nakai K, et al.
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1817-1818
  • Peer Reviewed
• [Journal Article] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation. (2010)
  • Author(s): Yamamoto T, et al.
  • Journal Title: Proceedings of 14th International congress on neutron capture therapy Pages: 7-7
• [Presentation] 招待講演シンポジウム「がんの熱中性子捕捉療法(BNCT)‐治療の現状と将来展望」悪性脳腫瘍のBNCT(加速器計画も含む) (2012)
  • Author(s): 山本哲哉
  • Organizer: 第127回日本医学放射線学会 北日本地方会
  • Place of Presentation: 仙台
• [Presentation] Boron Neutron Capture Therapy for Glioblastoma : Clinical Trials and Institutional Experience (2011)
  • Author(s): Tetsuya Yamamoto
  • Organizer: 6^<th> Young Boron Neutron Capture Therapy Meeting
  • Place of Presentation: Taiwan(招待講演)
  • Year and Date: 2011-12-07
• [Presentation] Invited lecture. Boron Neutron Capture Therapy for Glioblastoma: Clinical Trials and Institutional Experience (2011)
  • Author(s): Yamamoto T
  • Organizer: 6th Young Researchers BNCT Meeting
  • Place of Presentation: Taiwan
  • Year and Date: 2011-12-06
• [Presentation] Invited lecture. Boron Neutron Capture Therapy for Newly-Diagnosed Glioblastoma (2011)
  • Author(s): Yamamoto T
  • Organizer: 2011 BNCT Workshop on Clinical Applications
  • Place of Presentation: Taipei(Taiwan)
• [Presentation] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation (2010)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Miszumoto M, Tuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma (2010)
  • Author(s): Nakai K, Yamamoto T, Kageji T, Kumada H, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] BNCT and other emerging treatments for malignant glioma (2010)
  • Author(s): Matsumura A, Yamamoto T, Ishikawa E,Nakai K, Endo K, Takano S, Shibata Y
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] The staius of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation. (2010)
  • Author(s): Yamamoto T, et al.
  • Organizer: 14th International congress on neutran capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] ホウ素中性子捕捉療法の現状と課題 (2010)
  • Author(s): 山本哲哉
  • Organizer: 第8回東京理科大学DDS研究センターシンポジウム
  • Place of Presentation: 東京理科大学(東京)
  • Year and Date: 2010-10-15
• [Presentation] がん治療の最前線としてのBNCT
  • Author(s): 山本哲哉
  • Organizer: 新しいがん治療BNCT-難治性がんの克服を目指して-
  • Place of Presentation: つくばエキスポセンター
  • Invited
• [Presentation] 中性子でガン細胞を狙い撃ち 中性子捕捉療法
  • Author(s): 山本哲哉
  • Organizer: 日本中性子科学会市民講座
  • Place of Presentation: 京都大学
  • Invited
• [Presentation] 招待講演シンポジウム「がんの熱中性子捕捉療法（BNCT)‐治療の現状と将来展望」悪性脳腫瘍のBNCT(加速器計画も含む)
  • Author(s): 山本哲哉
  • Organizer: 第127回日本医学放射線学会北日本地方会
  • Place of Presentation: 東北大学
  • Invited
• [Book] Non-operative BNCT for GBM, in Neutron Capture Therapy, (Sauerwein W, Wittig A, Moss R, Nakagawa Y, Eds.) (2012)
  • Author(s): Yamamoto T and Matsumura A
  • Publisher: Springer
• [Book] Neutron Capture Therapy (2012)
  • Author(s): Sauerwein W
  • Total Pages: 553
  • Publisher: Springer
• [Book] Tumors of the Central Nervous System, Vol. 2 1st edition., Chapter 25. GLIOBLASTOMA: BORON NEUTRON CAPTURE THERAPY, (Hayat, M.A. Eds.) (2011)
  • Author(s): Yamamoto T, Nakai K, KumadaH
  • Publisher: Springer
• [Book] 特集 岐路に立つホウ素中性子捕捉療法.医師の立場‐脳神経外科医の視点から (2011)
  • Author(s): 山本哲哉
  • Publisher: エネルギーレビュー
• [Book] Tumors of the Central Nervous System, Volume 2 Gliomas : Glioblastoma (Part 2) Series : Tumors of the Central Nervous System, Vol.2 1st Edition. Chapter 25. GLIOBLASTOMA : BORON NEUTRON CAPTURE THERAPY (2011)
  • Author(s): Yamamoto T, Nakai K, Kumada H
  • Total Pages: 479
  • Publisher: Springer
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/chs/clinical_sciences/te_yamamoto.htm