| Project/Area Number |
22591605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
NAKAMURA Hiroyuki 学習院大学, 理学部, 教授 (30274434)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射線脳外科学 / ホウ素中性子捕捉療法 / BSH / BSO / 中性子捕捉療法 / グルタチオン / BNCT |
|---|
| Research Abstract |
In the previous study, we reported that combined use of sodium borocaptate (BSH) and buthionine sulfoximine (BSO) in BNCT enhanced tissue boron uptake in the rat subcutaneous tumor model, where BSO and BSH were administered simultaneously. In the present study, we used a brain tumor model, and rats were pretreated with BSO before BSH injection. By this method, the blood boron concentration was about 20 times higher in comparison with the BSO- (minus) group, and in other tissues (brain tumor, subcutaneous tumor, muscles, liver, kidney) the same tendency of increasing concentration was observed. We suggest that tumor-specific redox regulatory mechanisms are necessary to enhance tumor uptake of boron.
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