Roles of FABP and its regulating factors on neurogenesis after spinalcord injury

• Project/Area Number: 22591607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Yamanashi
• Principal Investigator: UCHIDA Mikito 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (30313795)
• Co-Investigator(Kenkyū-buntansha): HORIKOSHI Toru 山梨大学, 大学院・医学工学総合研究部, 准教授 (50209300)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脊髄損傷 / 脂肪酸結合蛋白 / 神経新生 / 神経細胞保護 / FABP / 神経再生

Research Abstract

In this study, we examined expression change of fatty acid binding protein (FABP)and evaluated the effects of FABP gene knockout on neuronal injury, neurogenesis andfunctional recovery after spinal cord injury (SCI). FABP is upregulated and mainlyexpressed in proliferative astrocytes after SCI. sparing of ventral neurons and motorfunction recovery were significantly worse in the knockout mice. Neurogenesis washardly observed in this spinal compression model. These data indicate that FABP couldhave a neuroprotective role and might be associated with proliferation of astrocytesafter SCI.