| Project/Area Number |
22591612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAMASAKI Fumiyuki 広島大学, 大学院・医歯薬保健学研究院, 助教 (60444692)
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| Co-Investigator(Kenkyū-buntansha) |
KURISU Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
SUGIYAMA Kazuhiko 広島大学, 病院, 教授 (30243554)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | glioma / EGFR / PEA-15 / erlotnib / diffuseion-weighted imaging / gemcitabine / bevacizumab / seudo-response / erlotinib / DWI / pseudo-response / diffuseion-weighterd imaging / apparent diffusion coefficient / pseudo-resonse |
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| Research Abstract |
PEA-15 expression level, that is the downstream molecule of EGFR signal pathway, was inversely associated with WHO grade and may serve as an important prognostic factor for high-grade astrocytomas. High PEA-15 expression level displayed a significantcorrelation with longer overall survival (OS) in high-grade astrocytomas (P = 0.0024). Gemcitabine increased the cytotoxic effect of erlotinib by downregulating p-Akt in EGFR-overexpressing cells with either intrinsic or acquired erlotinib resistance. The study of advanced MR imaging about brain tumors revealed that the MRS detection of lactate is a prognostic factor in patients with diffuse intrinsic pontine glioma. Calculating the ADC value is useful for distinguishing lymphoma from glioblastoma. The lowest degree of overlapping and a better inverse correspondence with tumor cellularity were obtained with ADCMIN at b-4000s/mm2 at 3 T MRI. High b-value DWI reflects cell density more accurately thanregular b-value DWI. Inpatients with recurrent glioma, high b-value diffusion-weighted criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab
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