Investigation of the molecular mechanism of invasion in CNS lymphomausing inoculation animal models in the brain and development of noveltreatment
| Project/Area Number |
22591615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
MAKINO Keishi 熊本大学, 医学部附属病院, 講師 (90381011)
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Junichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296)
NAKAMURA Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳腫瘍学 / 悪性リンパ腫 / fatty acid synthase / IDH1 / エネルギー代謝 / 中枢神経 / 悪性腫瘍 / glucose transporter 1 / 動物モデル / 浸潤 / eIF4E / α2,6-sialyltransferase |
|---|
| Research Abstract |
In order to identify the molecules related to growth and invasion ofcentral nervous system (CNS) lymphoma, we investigated the expression of glucosetransporter 1 (Glut 1), fatty acid synthase (F AS) and 2, 6-sialyltransferase. Weperformed immunohistochemical analysis using specific antibodies for each molecule. Intwenty-three of twenty-five cases with CNS lymphomas and all nine cases with CNSinvasion of systemic lymphoma, positive expression of 2,6-sialyltransferase was found.Furthermore, positive expression of F AS was found in 70.3 % and that of Glut 1 was foundin 44.4 % of twenty-seven cases with lymphomas. These data suggested that thesemetabolic or invasion related molecules might be novel therapeutic targets for CNSlymphoma
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Induction of autophagic cell death ofglioma-initiating cells bycell-penetrating d-isomer peptidesconsisting of Pas and the p53 C-terminus2012
Author(s)
Ueda Y, Wei FY, Hide TI, Michiue H,Takayama K, Kaitsuka T, Nakamura H, MakinoK, Kuratsu JI, Futaki S, Tomizawa K
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Journal Title
Biomaterials
Volume: 33(35)
Pages: 9061-9069
Related Report
Peer Reviewed
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[Journal Article] macrophage/ microglial cells induceactivation of Stat3 in primary centralnervous system lymphoma2011
Author(s)
Komohara Y, Horlad H, Ohnishi K, Ohta K,Makino K, Hondo H, Yamanaka R, Kajiwara K,Saito T, Kuratsu J, Takeya M
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Journal Title
J Clin Exp Hematop
Volume: 51(2)
Pages: 93-99
Related Report
Peer Reviewed
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[Journal Article] Does addingFDG-PET to MRI improve the differentiation between primary cerebral lymphoma andglioblastoma?2011
Author(s)
Makino K, Hirai T, Nakamura H, MurakamiR, Kitajima M, Shigematsu Y, Nakashima R,Shiraishi S, Uetani H, Iwashita K, Akter M,Yamashita Y, Kuratsu JI
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Journal Title
Observer performance study.Annals of nuclear medicine
Volume: 25(6)
Pages: 432-438
Related Report
Peer Reviewed
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