| Project/Area Number |
22591615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
MAKINO Keishi 熊本大学, 医学部附属病院, 講師 (90381011)
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Junichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296)
NAKAMURA Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳腫瘍学 / 悪性リンパ腫 / fatty acid synthase / IDH1 / エネルギー代謝 / 中枢神経 / 悪性腫瘍 / glucose transporter 1 / 動物モデル / 浸潤 / eIF4E / α2,6-sialyltransferase |
|---|
| Research Abstract |
In order to identify the molecules related to growth and invasion ofcentral nervous system (CNS) lymphoma, we investigated the expression of glucosetransporter 1 (Glut 1), fatty acid synthase (F AS) and 2, 6-sialyltransferase. Weperformed immunohistochemical analysis using specific antibodies for each molecule. Intwenty-three of twenty-five cases with CNS lymphomas and all nine cases with CNSinvasion of systemic lymphoma, positive expression of 2,6-sialyltransferase was found.Furthermore, positive expression of F AS was found in 70.3 % and that of Glut 1 was foundin 44.4 % of twenty-seven cases with lymphomas. These data suggested that thesemetabolic or invasion related molecules might be novel therapeutic targets for CNSlymphoma
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