| Project/Area Number |
22591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAMURA Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Keishi 熊本大学, 医学部附属病院, 講師 (90381011)
HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820)
KURATSU Jun-ichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Seishi 東京大学, 医学部付属病院, 准教授 (60292900)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳腫瘍学 / スニップマイクロアレイ / 薬剤耐性 / グリオーマ幹細胞 / GSC移植動物モデル / 薬剤耐性に関する遺伝子 / 遺伝子プロファイリング / テモダール耐性 / グリオーマ幹細胞(GSC) / 幹細胞培養 / 悪性グリオーマ / 抗がん剤耐性株 |
|---|
| Research Abstract |
We focused on the biological property of glioma cancer stem cellto investigate the mechanism of drug resistance in malignant glioma. We could maintainthe property of stem cell by culturing under the special condition and did an experimentof the biology of drug resistance. We investigated the genomic profiles of glioma cellsusing SNIP-microarray and found that genetic alterations such as p53 reduced thesensitivity of drugs. While, we also found that differentiation of the glioma cellscontributed to the sensitivity of drugs
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