Towards molecular-guided personalized therapy of gliomas -clarifyingthe indication of neoadjuvant approach for gliomas-

• Project/Area Number: 22591619
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Keio University
• Principal Investigator: YOSHIDA Kazunari 慶應義塾大学, 医学部, 教授 (70166940)
• Co-Investigator(Kenkyū-buntansha): SASAKI Hikaru 慶應義塾大学, 医学部, 講師 (70245512)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脳腫瘍学 / 脳腫瘍 / 神経膠腫 / 個別化治療 / 1p/19q / neoadjuvant chemotherapy / 術前化学療法 / MGMT / 遺伝子 / 癌 / グリオーマ / 1P / 19q / neoadjuvant

Research Abstract

We have conducted molecular/genetic analysis on more than 400gliomas to establish molecular classification of gliomas. As a result, gliomas of grade2-3 were shown to be classified into subgroups based on genetic profile that correlatewell with prognosis.

Research Products

• [Journal Article] Optic nerveseeding of atypical meningiomaspresenting with subacute visual loss:two case reports with geneticcharacterization (2013)
  • Author(s): Kitamura Y, Akiyama T, Sasaki H,Hayashi Y, Yoshida K
  • Journal Title: Journal of Neurosurgery
  • Peer Reviewed
• [Journal Article] Subgrouping of gliomas on the basis ofgenetic profiles (2013)
  • Author(s): Hirose Y, Sasaki H, Abe M, Hattori N,Adachi K, Nishiyama Y, Nagahisa S,Hayashi T, Hasegawa M, Yoshida K
  • Journal Title: Brain TumorPathology
  • Peer Reviewed
• [Journal Article] Surgicalnavigation-assisted endoscopicbiopsy is feasible for safe andreliable diagnosis of unresectablesolid brain tumors (2013)
  • Author(s): Nagahisa S, Watabe T, Sasaki H,Nishiyama Y, Hayashi T, Hasegawa M,Hirose Y
  • Journal Title: NeurosurgicalReview
  • Peer Reviewed
• [Journal Article] Infratentorial low-gradeoligoastrocytoma with aggressiveclinical behavior in an adult: a casereport with genetic characterization (2013)
  • Author(s): Sano K, Toda M, Sasaki H, Kitamura Y,Mikami S, Hirato J, Inoue S, Kawase T,Yoshida K
  • Journal Title: Brain Tumor Pathology Volume: 30(2) Pages: 99-103
  • Peer Reviewed
• [Journal Article] Immunoglobulin G4-related intracranial inflammatory pseudotumours along both the oculomotor nerves (2013)
  • Author(s): Tomio R, Ohira T, Wenlin D, Yoshida K
  • Journal Title: BMJ Case Reports Volume: - Pages: bcr2012007320-bcr2012007320
  • DOI: 10.1136/bcr-2012-007320
  • Peer Reviewed
• [Journal Article] Supratentorial neurenteric cyst with spontaneous repetitive intracystic hemorrhage mimicking brain abscess: a case report (2013)
  • Author(s): Kitamura Y, Sasaki H, Hashiguchi A, Momoshima S, Shidoh S, Yoshida K
  • Journal Title: Neurosurg Rev Volume: -
  • Peer Reviewed
• [Journal Article] Dumbbell-shaped Abducens Schwannoma (2013)
  • Author(s): Shibao S, Hayashi S, Yoshida K
  • Journal Title: Neurol Med Chir Volume: -
  • Peer Reviewed
• [Journal Article] Procalcitonin as an Early Diagnostic Marker for Ventriculoperitoneal Shunt Infections. Literature review (2013)
  • Author(s): Tomio R, Akiyama T, Shibao S, Yoshida K
  • Journal Title: Surgical Infections Volume: -
  • Peer Reviewed
• [Journal Article] Kohmura E Immunohistochemicaland molecular genetics study of agranular cell astrocytoma: A casereport of malignant transformation toa glioblastoma (2012)
  • Author(s): Ishii T, Mizukawa K, Sasayama T,Sasaki H, Hayashi S, Nakamizo S,Tanaka H, Tanaka K, Hara S, Hirai C,Itoh T
  • Journal Title: Neuropathology
  • Peer Reviewed
• [Journal Article] Clinical,histological, and genetic features offourth ventricle ependymoma in theelderly (2012)
  • Author(s): Hayashi T, Inamasu J, Kanai R, SasakiH, Shinoda J, Hirose Y
  • Journal Title: Neurologia Medico-Chirurgica Volume: 52(8) Pages: 611-6
  • Peer Reviewed
• [Journal Article] Molecular and genetic profiles ofradiographically defined de novomeningiomas (2012)
  • Author(s): Kitamura Y, Sasaki H, Yoshida K
  • Journal Title: J Neurooncol Volume: 108(1) Pages: 37-44
  • Peer Reviewed
• [Journal Article] Downregulation ofKIF23 suppresses glioma proliferation. (2012)
  • Author(s): Takahashi S, Fusaki N, Ohta S, IwahoriY, Iizuka Y, Inagawa K, Kawakami Y,Yoshida K, Toda M
  • Journal Title: J Neurooncol Volume: 106(3) Pages: 519-529
  • Peer Reviewed
• [Journal Article] Hemorrhagic onset of cerebellarpilocytic astrocytoma in an adult: acase report and review of theliterature implying a possible relation of degenerative vascularchanges to the massive intratumoralhemorrhage (2012)
  • Author(s): Shibao S, Kimura T, Sasaki H, FujiwaraH, Akiyama T, Ueno M, Shidou S, YoshidaK
  • Journal Title: Brain Tumor Pathology Volume: 29(2) Pages: 96-102
  • Peer Reviewed
• [Journal Article] Optic nerve sheath solitary fibrous tumor (2012)
  • Author(s): Kitamura Y, Akiyama T, Hirose S, Yoshida K
  • Journal Title: Acta Neurochir (Wien) Volume: 154 (4) Issue: 4 Pages: 633-635
  • DOI: 10.1007/s00701-011-1257-1
  • Peer Reviewed
• [Journal Article] Molecular and genetic profiles of radiographically defined de novo meningiomas (2012)
  • Author(s): Kitamura Y, Sasaki H, Yoshida K
  • Journal Title: Journal of Neuro-Oncology Volume: (in press) Issue: 1 Pages: 37-44
  • DOI: 10.1007/s11060-012-0797-4
  • Peer Reviewed
• [Journal Article] Application of endoscopic transsphenoidal approach to true type transsellar transsphenoidal meningoencephalocele in an adult: A case report and literature review (2012)
  • Author(s): Saito K, Toda M, Tomita T, Sano K, Ogawa K, Yoshida K
  • Journal Title: Acta Neurochir (Wien) Volume: 154 Issue: 8 Pages: 1511-1515
  • DOI: 10.1007/s00701-012-1346-9
  • Peer Reviewed
• [Journal Article] Epidural anterior petrosectomy with subdural visualization of sphenobasal vein via the anterior transpetrosal approach-technical case report. (2012)
  • Author(s): Ichimura S, Yoshida K, Kagami H, Inaba M, Orii M, Kitamura Y, Saga I, Toda M
  • Journal Title: Neurosurg Rev Volume: 35 Issue: 4 Pages: 609-613
  • DOI: 10.1007/s10143-012-0405-2
  • Peer Reviewed
• [Journal Article] Recanalisation of spontaneously occluded vertebral artery dissection after subarachnoid haemorrhage (2012)
  • Author(s): Akiyama T, Onozuka S, Horiguchi T, Yoshida K
  • Journal Title: Neurosurg Rev Volume: 35 (4) Issue: 4 Pages: 615-620
  • DOI: 10.1007/s10143-012-0416-z
  • Peer Reviewed
• [Journal Article] Plastic relocation of motor cortex in a patient with LGG (low grade glioma) confirmed by NBS (navigated brain stimulation) (2012)
  • Author(s): Takahashi S, Jussen D, Vajkoczy P, Picht T
  • Journal Title: Acta Neurochir (Wien) Volume: 154 (11) Issue: 11 Pages: 2003-2008
  • DOI: 10.1007/s00701-012-1492-0
  • Peer Reviewed
• [Journal Article] Development Traumatic Brain Injury Computer User Interface for Disaster Area in Indonesia Supported by Emergency Broadband Access Network (2012)
  • Author(s): Agung Budi Sutiono, Hirohiko Suwa, Toshizumi Ohta, Muh-Zafrullah Arifin, Yohei Kitamura, Kazunari Yoshida, Daduk Merdika, Andri Qiantori, Iskandar
  • Journal Title: Journal of Medical Systems Volume: Vol.36 Issue: 6 Pages: 3955-3966
  • DOI: 10.1007/s10916-012-9867-6
  • Peer Reviewed
• [Journal Article] Spontaneous spinal epidural hematoma (SSEH) after coil embolization of cerebral aneurysm: Implication of high SSEH frequency in East Asia (2012)
  • Author(s): Kitamura Y, Onozuka S, Ichimura S, Yoshida K
  • Journal Title: Clin Neurol Neurosurg Volume: 20 (2) Issue: 5 Pages: 99-103
  • DOI: 10.1016/j.clineuro.2012.06.034
  • Peer Reviewed
• [Journal Article] Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: two case reports with genetic characterization (2012)
  • Author(s): Kitamura Y, Akiyama T, Sasaki H, Hayashi Y, Yoshida K
  • Journal Title: J Neurosurg Volume: -
  • Peer Reviewed
• [Journal Article] Molecularcharacteristics of pediatricnon-ependymal, non-piloccyticgliomas associated with resistance totemozolomide (2011)
  • Author(s): Ezaki T, Sasaki H, Hirose Y, Miwa T,Yoshida K, Kawase T
  • Journal Title: Mol Med Report Volume: 4(6) Pages: 1101-1105
  • Peer Reviewed
• [Journal Article] Brain TumorStem Cells and Anti-AngiogenicTherapy. Cancer Stem Cells - TheCutting Edge (2011)
  • Author(s): Saito K, Yoshida K, Toda M
  • Journal Title: Stanley Shostak eds.InTech, Croatia
  • Peer Reviewed
• [Journal Article] A glioblastoma arising from theattached region where a meningioma hadbeen totally removed (2011)
  • Author(s): Ohba S, Shimizu K, Shibao S, Miwa T,Nakagawa T, Sasaki H, Murakami H
  • Journal Title: Neuropathology Volume: 31(6) Pages: 606-11
  • Peer Reviewed
• [Journal Article] Rapid spontaneousregression of multicentric infantilemyofibromatosis in the posteriorfossa and lumbar vertebra. (2011)
  • Author(s): Miwa T, Oi S, Nonaka Y, Tamogami R,Sasaki H, Akiyama M, Yuza Y, Yokoi K,Yokokawa Y, Ida H
  • Journal Title: Child`s Nervous System Volume: 27 (3) Pages: 491-6
  • Peer Reviewed
• [Journal Article] Aggressive largecell medulloblastoma extending to theextracranial region in brain-deadstatea. (2011)
  • Author(s): Miwa T, Oi S, Nonaka Y, Tamogami R,Sasaki H, Akiyama M, Yuza Y, Yokoi K,Yokokawa Y, Ida H
  • Journal Title: Child`s Nervous System Volume: 27(8) Pages: 1341-6
  • Peer Reviewed
• [Journal Article] WholeGenome Analysis From MicrodissectedTissue Revealed Adult SupratentorialGrade II-III Gliomas Are Divided IntoClinically Relevant Subgroups byGenetic Profile (2011)
  • Author(s): Hirose Y, Sasaki H, Miwa T, Ohba S,Ikeda E, Abe M, Ikeda S, Kobayashi M,Kawase T, Hasegawa M, Yoshida K
  • Journal Title: Neurosurgery Volume: 69(2) Pages: 376-390
  • Peer Reviewed
• [Journal Article] Downregulation of uPARAP mediatescytoskeletal rearrangements anddecreases invasion and migrationproperties in glioma cells (2011)
  • Author(s): Takahashi S, Yamada-Okabe H, Hamada K,Ohta S, Kawase T, Yoshida K, Toda M
  • Journal Title: Jneurooncol Volume: 103(2) Pages: 267-276
  • Peer Reviewed
• [Journal Article] Functional analysis of HOXD9 in humangliomas and glioma cancer stem cells (2011)
  • Author(s): Tabuse M, Ohta S, Ohashi Y, Fukaya R,Misawa A, Yoshida K, Kawase T, Saya H,Thirant C, Chneiweiss H, Matsuzaki Y,Okano H, Kawakami Y, Toda M.
  • Journal Title: Mol Cancer Volume: 10(60) Pages: 1-14
  • Peer Reviewed
• [Journal Article] Single copy gainof chromosome 1q is a negativeprognostic marker in pediatricnon-ependymal (2011)
  • Author(s): Miwa T, Hirose Y, Sasaki H, Ezaki T,Yoshida K, Kawase T
  • Journal Title: non-pilocytic gliomas.Neurosurgery Volume: 68(1) Pages: 206-212
  • Peer Reviewed
• [Journal Article] Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult : a case report and review of the literature implying a possible relation of de generative vascular changes to the massive intratumoral hemorrhage (2011)
  • Author(s): Shibao S, Kimura T, Sasaki H, Fujiwara H, Akiyama T, Ueno M, Shidou S, Yoshida K
  • Journal Title: Brain Tumor Pathol Volume: (in press) Issue: 2 Pages: 96-102
  • DOI: 10.1007/s10014-011-0068-7
  • Peer Reviewed
• [Journal Article] Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile (2011)
  • Author(s): Hirose Y, Sasaki H, Miwa T, Ohba S, Ikeda E, Abe M, Ikeda S, Kobayashi M, Kawase T, Hasegawa M, Yoshida K
  • Journal Title: Neurosurgery Volume: 69(2) Issue: 2 Pages: 376-90
  • DOI: 10.1227/neu.0b013e318212bcd8
  • Peer Reviewed
• [Journal Article] A glioblastoma arising from the attached region where a meningioma had been totally removed (2011)
  • Author(s): Ohba S, Shimizu K, Shibao S, Miwa T, Nakagawa T, Sasaki H, Murakami H
  • Journal Title: Neuropathology Volume: 31(6) Issue: 6 Pages: 606-611
  • DOI: 10.1111/j.1440-1789.2011.01198.x
  • Peer Reviewed
• [Journal Article] Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead statea (2011)
  • Author(s): Miwa T, Oi S, Nonaka Y, Tamogami R, Sasaki H, Akiyama M, Yuza Y, Yokoi K, Yokokawa Y, Ida H
  • Journal Title: Childs Nerv Syst Volume: 27(8) Issue: 8 Pages: 1341-1346
  • DOI: 10.1007/s00381-011-1450-9
  • Peer Reviewed
• [Journal Article] Molecular characteristics of pediatric non-ependymal, non-pilocytic gliomas associated with resistance to temozolomide (2011)
  • Author(s): Ezaki T, Sasaki H, Hirose Y, Miwa T, Yoshida K, Kawase T
  • Journal Title: Mol Med Report Volume: 4 Pages: 1101-1105
  • DOI: 10.3892/mmr.2011.573
  • Peer Reviewed
• [Journal Article] Single coy gain of chromosome 1q is a negative prognostic marker in pediaric non-ependymal, non-pilocytic gliomas. (2011)
  • Author(s): Miwa, et al.
  • Journal Title: Childs Nerv Syst Volume: 27 Pages: 491-496
  • Peer Reviewed
• [Journal Article] Single coy gain of chromosome 1q is a negative prognostic marker in pediaric non-ependymal, non-pilocytic gliomas. (2011)
  • Author(s): Miwa, et al.
  • Journal Title: Neurosurgery Volume: 68 Pages: 206-212
  • Peer Reviewed
• [Journal Article] Clear cell meningiomas : three case reports with genetic charact erization and review of the literature. (2010)
  • Author(s): Ohba S, et al.
  • Journal Title: Neurosurgery Volume: 67
  • Peer Reviewed
• [Journal Article] 退形成性神経膠腫の多施設共同試験 -世界における動向- (2010)
  • Author(s): 佐々木光
  • Journal Title: 新時代の脳腫瘍学(日本臨床 増刊) Volume: 68 Pages: 616-627
  • Peer Reviewed
• [Journal Article] Supratentorial neurenteric cyst withspontaneous repetitive intracystichemorrhage mimicking brain abscess: acase report
  • Author(s): Kitamura Y, Sasaki H, Hashiguchi A,Momoshima S, Shidoh S, Yoshida K
  • Journal Title: Neurosurg Rev Volume: (in press)
  • Peer Reviewed
• [Presentation] Molecular-guided neoadjuvantapproach for chemosensitive gliomas (2013)
  • Author(s): Sasaki H, Hirose Y, Katayama M, YazakiT, Kitamura Y, Toda M, Ohira T, YoshidaK
  • Organizer: 10th Meeting of Asian Society forNeuro-Oncology
  • Place of Presentation: Mumbai(India)
  • Year and Date: 2013-03-23
• [Presentation] 1p/19qcodeleted glioma における予後因子の検討 (2012)
  • Author(s): 林佐衣子、佐々木光、木村徳宏、中村 匠、三輪 点、廣瀬雄一、吉田一成
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島(広島)
  • Year and Date: 2012-11-26
• [Presentation] 頭蓋底脊索腫の分子生物学的解析と予後因子の検討 (2012)
  • Author(s): 北村洋平、佐々木光、木村徳宏、三輪 点、高橋里史、河瀬 斌、吉田一成
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-10-17
• [Presentation] Low-grade glioma に対する遺伝子診断に基づくneoadjuvantapproach (2012)
  • Author(s): 佐々木光、廣瀬雄一、片山 真、 矢崎貴仁、北村洋平、戸田正博、大平貴之、吉田一成
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-10-17
• [Presentation] DNA コピー数異常とIDH1 変異に基づいた神経膠腫の遺伝学的分類の再構築 (2012)
  • Author(s): 廣瀬雄一、佐々木光、服部夏樹、山田康博、安達一英、林 拓郎、長久伸也、西山悠也、長谷川光広、川瀬 司、吉田耕一郎、安倍雅人
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-10-17
• [Presentation] Molecular-guided neoadjuvant aproachfor gliomas (2012)
  • Author(s): Sasaki H, Hirose Y, Katayama M, YazakiT, Toda M, Ohira T, Yoshida K
  • Organizer: The 19th InternationalBrain Tumor Research and TherapyConference
  • Place of Presentation: NiagaraFalls(Canada)
  • Year and Date: 2012-06-21
• [Presentation] 診断困難例における分子生物学的検討 (2012)
  • Author(s): 林佐衣子、佐々木光、亀山香織、吉田一成
  • Organizer: 第30回日本脳腫瘍病理学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2012-05-25
• [Presentation] Moleclar-guided neoadjuvant approachfor gliomas regardless of histology (2012)
  • Author(s): Sasaki H, Hirose Y, Katayama M, YazakiT, Toda M, Ohira T, Yoshida K
  • Organizer: 第4回国際脳腫瘍病理シンポジウム
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2012-05-24
• [Presentation] Management of gliomas with molecular prognostic/predictive factors (2012)
  • Author(s): 佐々木光
  • Organizer: 第23回東京脳腫瘍治療懇話会
  • Place of Presentation: センナュリーハイアット東京(東京)(招待講演)
  • Year and Date: 2012-01-13
• [Presentation] Glioma の遺伝子診断とneoadjuvantapproach (2011)
  • Author(s): 佐々木光、廣瀬雄一、片山 真、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第29回日本脳腫瘍学会学術集会
  • Place of Presentation: 下呂温泉(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] Gliomaの遺伝子診断とneoadjuvant approach (2011)
  • Author(s): 佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 下呂温泉水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] De novo meningiomaの分子生物学的特徴 (2011)
  • Author(s): 北村洋平、佐々木光、吉田一成
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 下呂温泉水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] -1p/19q腫瘍群における放射線学的特徴と有効な補助療法に関する検討 (2011)
  • Author(s): 西山悠也、長久伸也、安達一英、林拓郎、吉田耕一郎、川瀬司、長谷川光広、佐々木光、安倍雅人、片田和広、平井達夫、廣瀬雄一
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 下呂温泉水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] Low-grade gliomaの遺伝子診断とneoadjuvant approach (2011)
  • Author(s): 佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-10-14
• [Presentation] Low-gradeglioma の遺伝子診断とneoadjuvantapproach (2011)
  • Author(s): 佐々木光、廣瀬雄一、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 日本脳神経外科学会第70回学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-10-13
• [Presentation] Grade2-3 グリオーマに対する遺伝子診断に基づくneoadjuvant approach (2011)
  • Author(s): 佐々木光、廣瀬雄一、片山 真、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第16回日本脳腫瘍の外科学会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-09-10
• [Presentation] Grade 2-3グリオーマに対する遺伝子診断に基づくneoadjuvant approach (2011)
  • Author(s): 佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第16回日本脳腫瘍の外科学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-10
• [Presentation] Gliomaにおける-1p/19q、+7各腫瘍群の放射線学的特徴に関する検討とその生物学的意義の考察 (2011)
  • Author(s): 西山悠也、長久伸也、安達一英、吉田耕一郎、川瀬司、長谷川光広、佐々木光、安倍雅人、片田和広、廣瀬雄一
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-21
• [Presentation] DNAコピー数異常とIDH1変異の解析による神経膠腫の遺伝学的分類と臨床像 (2011)
  • Author(s): 服部夏樹、佐々木光、安達一英、長久伸也、吉田耕一郎、安倍雅人、川瀬司、長谷川光広、廣瀬雄一
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-21
• [Presentation] 詳細な遺伝子検索を施行し得たmulticentric gliomaの1例 (2011)
  • Author(s): 原岡怜、秋元治朗、深見真二郎、中島伸幸、原岡襄、佐々木光
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-21
• [Presentation] WHO grade II-III gliomaの遺伝学的特徴と臨床像 (2011)
  • Author(s): 廣瀬雄一、佐々木光、安倍雅人、長久伸也、安達一英、吉田耕一郎、西山悠也、服部夏樹、川瀬司、長谷川光広
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-20
• [Presentation] 第7染色体DNAコピー数増加および1p/19q共欠失を示さないグリオーマにおける、遺伝学的異常と臨床像の検討 (2011)
  • Author(s): 安達一英、佐々木光、長久伸也、吉田耕一郎、服部夏樹、西山悠也、川瀬司、長谷川広、安倍雅人、廣瀬雄一
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-20
• [Presentation] 妊娠中に発症した脳腫瘍における分子生物学的解析 (2011)
  • Author(s): 林佐衣子、佐々木光、木村徳宏、北村洋平、秋山武紀、吉田一成
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-20
• [Presentation] 神経膠腫再発に伴う分子マーカーの変化と治療抵抗性獲得についての検討 (2010)
  • Author(s): 佐々木光、梶川慶太、廣瀬雄一、北村洋平、戸田正博、吉田一成
  • Organizer: 第28回日本脳腫瘍学会学術集会
  • Place of Presentation: 軽井沢プリンスホテル(軽井沢)
  • Year and Date: 2010-11-27
• [Presentation] Usefulness of C11 methionine-PET in early diagnosis of recurrent gliomas treated by temozolomide -two case reports-. (2010)
  • Author(s): Sasaki, et al.
  • Organizer: 15th Annual meeting of the Society for Neuro-Oncelogy
  • Place of Presentation: Montreal
  • Year and Date: 2010-11-19
• [Presentation] 神経膠腫に対するneoadjuvant approach (2010)
  • Author(s): 佐々木光、廣瀬雄一、矢崎貴仁、戸田正博、大平貴之、吉田一成
  • Organizer: 第69回日本脳神経外科学会
  • Place of Presentation: 福岡コンベンションセンター(福岡)
  • Year and Date: 2010-10-27
• [Presentation] 神経膠腫に対するneoadjuvant approach (2010)
  • Author(s): 佐々木光, ほか
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] Low-grade gliomaの遺伝子診断とneoadjuvant approach (2010)
  • Author(s): 佐々木光, ほか
  • Organizer: 第15回日本脳腫瘍の外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-02
• [Presentation] Molecular-guided neoadjuvant approach for gliomas. (2010)
  • Author(s): 佐々木光
  • Organizer: 第3回三重脳腫瘍セミナー
  • Place of Presentation: 津
  • Year and Date: 2010-09-10
• [Presentation] Moleclar-guided neoadjuvant approach for gliomas regardless of histology
  • Author(s): Sasaki H, Hirose Y, Katayama M, Yazaki T, Toda M, Ohira T, Yoshida K
  • Organizer: 第4回国際脳腫瘍病理シンポジウム
  • Place of Presentation: 名古屋国際会議場 （名古屋）
• [Presentation] 診断困難例における分子生物学的検討
  • Author(s): 林佐衣子、佐々木光、亀山香織、吉田一成
  • Organizer: 第30回日本脳腫瘍病理学会
  • Place of Presentation: 名古屋国際会議場 （名古屋）
• [Presentation] Molecular-guided neoadjuvant aproach for gliomas
  • Author(s): Sasaki H, Hirose Y, Katayama M, Yazaki T, Toda M, Ohira T, Yoshida K
  • Organizer: The 19th International Brain Tumor Research and Therapy Conference
  • Place of Presentation: Niagara Falls (Canada)
• [Presentation] 誘導型脳腫瘍幹細胞マウスモデルを用いた腫瘍起源細胞の多様性
  • Author(s): 嵯峨伊佐子、Sampetrean Oltea、大須賀覚、大西伸幸、杉原英志、 大久保淳、柴尾俊輔、吉田一成、佐谷秀行
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場 （大阪）
• [Presentation] Low-grade gliomaに対する遺伝子診断に基づくneoadjuvant approach
  • Author(s): 佐々木光、廣瀬雄一、片山 真、 矢崎貴仁、北村洋平、戸田正博、大平貴之、吉田一成
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場 （大阪）
• [Presentation] 頭蓋底脊索腫の分子生物学的解析と予後因子の検討
  • Author(s): 北村洋平、佐々木光、木村徳宏、三輪 点、高橋里史、河瀬 斌、吉田一成
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場 （大阪）
• [Presentation] グリオーマ抗原遺伝子EFTUD1の機能解析
  • Author(s): 斉藤 克也、戸田 正博、吉田 一成
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場 （大阪）
• [Presentation] 進行・再発悪性グリオーマに対するVEGFRワクチンの第１/2相臨床試験
  • Author(s): 戸田正博、斉藤克也、植田 良、佐々木光、吉田一成
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島 （広島）
• [Presentation] リボソーム合成阻害を介した治療標的分子としてのグリオーマ新規抗原EFTUD1の解析
  • Author(s): 斉藤克也、戸田正博、吉田一成
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島 （広島）
• [Presentation] 1p/19q codeleted gliomaにおける予後因子の検討
  • Author(s): 林佐衣子、佐々木光、木村徳宏、中村 匠、三輪 点、廣瀬雄一、吉田一成
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島 （広島）
• [Presentation] Molecular-guided neoadjuvant approach for chemosensitive gliomas
  • Author(s): Sasaki H, Hirose Y, Katayama M, Yazaki T, Kitamura Y, Toda M, Ohira T, Yoshida K
  • Organizer: 10th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Mumbai (India)
• [Book] 脳腫瘍 In: 今日の治療指針2012 (2012)
  • Author(s): 佐々木光,山口徹、北原光夫、福井次矢編
  • Total Pages: 2064
  • Publisher: 医学書院
• [Book] 今日の治療指針2012 (2012)
  • Author(s): 佐々木光
  • Publisher: 医学書院
• [Book] 星細胞腫の治療選択.In脳腫瘍実践ケーススタディ第2巻 (2010)
  • Author(s): 佐々木光
  • Publisher: 株式会社エサップ
• [Book] 膠芽腫の治療:PD or pseudoPD.In脳腫瘍実践ケーススタディ第2 (2010)
  • Author(s): 佐々木光
  • Publisher: 株式会社エサップ
• [Remarks]
  • URL: http://www.neurosurgery.med.keio.ac.jp/
• [Remarks] グリオーマの遺伝子解析と個別化治療
  • URL: http://www.neurosurgery.med.keio.ac.jp/