Contribution of The Pro-inflammatory Cytokines and Aquaporin 1 & 4 in the Progression
| Project/Area Number |
22591622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ラトケ嚢胞 / 炎症性サイトカイン / アクアポリン / ホルモン受容体 / サイトカイン / 炎症 |
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| Research Abstract |
Expression of water-channel aquoporin 1 and 4 in Rathke epithelium might stimulate to progression of cyst. Over-expression of androgen receptor in Rathke epithelium might induce proliferation with Rathke epithelium itself and inflammation in adenohypophysis. So aquaporin and androgen receptor might be novel target molecules totreat with symptomatic Rathke cleft cyst.
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Report
(4 results)
Research Products
(2 results)
