| Project/Area Number |
22591630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
HIRANO Kenichi 名古屋大学, 医学部附属病院, 医員 (50566974)
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| Co-Investigator(Kenkyū-buntansha) |
IMAGAMA Shiro 名古屋大学, 医学部附属病院, 助教 (40467288)
ANDO Kei 名古屋大学, 医学部附属病院, 病院助教 (40566973)
TAUCHI Ryoji 名古屋大学, 医学部附属病院, 医員 (50584744)
MURAMOTO Akio 名古屋大学, 医学部附属病院, 医員 (90597858)
MATSUI Hiroki 名古屋大学, 医学部附属病院, 医員 (70612802)
若尾 典充 名古屋大学, 医学系研究科, 特任助教 (80528802)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脊髄再生 / コンドロイチナーゼ ABC / 脊髄損傷 / 骨髄幹細胞 / GDNF / 遺伝子導入 / ケラタナーゼ / コンドロイチナーゼABC |
|---|
| Research Abstract |
We evaluated the recovery of motor and sensory function after spinal cord injury in the mammal. The efficacy of GDNF-expressing bone marrow stem cells and Ch-ABC for spinal cord injury in the beagle dogs was demonstrated as in the rodents. The optimal density of Ch-ABC was 0.05U/200μl for the recovery of motor function. We also demonstrated the inhibitory function of keratan sulfate for spinal cord regeneration. The efficacy of keratanase II; catabolic enzyme of keratan sulfate, for spinal cord regeneration was also demonstrated.
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