| Project/Area Number |
22591644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AJIRO Yasumitsu 日本大学, 医学部, 助教 (00424739)
OHSHIMA Masashi 日本大学, 医学部, 助教 (20526090)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脊椎脊髄病学 / 椎間板 / 脊椎固定術 / 内固定金属 / 合併症 / 予防 / 安全性 |
|---|
| Research Abstract |
To reduce adjacent disc problems after spinal fusion, a pedicle screw with a mobile metal-on-metal structure at the junction between the head and thread shaft of the screw was developped. The durability of this screw and biological reactions in the implanted mini-pigs were evaluated. None of the screws broke during the endurance test stressing. The mean amount of abrasion wear was 0.0338 g. In the zygapophyseal joints of the mini-pigs, implanted mobile-head screws, the amount of callus was small, and joint space was confirmed by CT. No metalloses as biological reactions were noted grossly around any of these screws. Novel screws with a mobile head were suggested to be highly durable, histologically safe.
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