| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Ossification of the posterior longitudinal ligament (OPLL) is an incurable disease of unknown cause, and its symptoms include spinal ligament ossification and a reduced range of motion of the limbs. After we determined the proteins that are deleted or reduced in OPLL via a proteomics analysis of the serum of patients with OPLL and healthy subjects, we created a knockout mouse model of OPLL. The knockout mice did not exhibit any special change at birth compared to wild-type mice, but we observed later increases in the weight and incidence of type 1 diabetes in the knockout mice. They also displayed hyperglycemia and after 8 months, a gait disorder (claudication) of the hind leg as well as OPLL on three-dimensional computerized tomography and through a non-decalcification bone tissue morphometric assessment.
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