| Project/Area Number |
22591653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Hitoshi 名古屋大学, 医学系研究科, 教授 (80173243)
TATEBE Masahiro 名古屋大学, 医学部附属病院, 講師 (60420379)
YAMAMOTO Michiro 名古屋大学, 医学部附属病院, 病院助教 (90528829)
OKUI Nobuyuki 名古屋大学, 医学部附属病院, 病院助教 (70547554)
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| Research Collaborator |
NATSUME Tadahiro 名古屋大学, 病院助教 (30624316)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 作業関連上肢筋骨格系障害 / mast cell / triptase / PAR2 / repeated minor trauma / VEGF / cytocine / PAR / 筋骨格系障害 / gelatinase(MMP) / tryptase / gelatinase (MMP) / Proteinase Activated Receptor (PAR) |
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| Research Abstract |
In work-related upper limb musculoskeletal disorders such as carpal tunnel syndrome and stenosing tenosynovitis, symptom duration correlated negativelywith pain severity and positively with disability. In pathological finding of tenosinovium, mast cell triptase which is an agonist of PAR2 was mainly express around vessels. Mast cell triptase correlated positively with cytokines such as TNF-α and IL-6. Weconsider that these factors were involved in pain severity. The expression of triptase decreased and the expression of VEGF increased over the course of the disease. Wethink that mast cell triptase plays an important role in the inflammation of the tenosynovium and pain severity.
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