| Project/Area Number |
22591654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
KATO Ko 三重大学, 大学院・医学系研究科, 教授 (20303729)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMINE Akihiko 三重大学, 大学院・医学系研究科, 准教授 (00335118)
NAKAMURA Tomoki 三重大学, 医学部附属病院, 助教 (50467362)
SATONAKA Haruhiko 三重大学, 大学院・医学系研究科, リサーチアソシエイト (60515485)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIDA Atsumasa 三重大学, 学長 (40176681)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨転移 / 磁性体温熱療法 / アクリジンオレンジ / ラジオ波焼灼術 / NFκB decoy / Acridine Orange / hyperthermia / minimally invasive surgery / NF-kappa B decoy |
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| Research Abstract |
We developed the novel physicochemical and molecular biological therapy for the metastatic bone tumors. First, we showed that NF-kappaB decoy suppress the cell invasion and cell growth of breast cancer cell line at the bone metastatic site, by inhibiting the expression of VCM-1and ICAM-1. Second, we demonstrated the effect of hyperthermic treatment strategy with magnetic nano-particle. Third, Photodynamic therapy(PDT) using acridine orange is proved to be effective treatment not only for the sarcoma, but also for metastatic bone tumors. Actually we started clinical application of PDT for the bone metastases. Finally, we developed the radiofrequency ablation (RFA) combined with thermo-sensitive liposome-embedding doxorubicin in an effort to safe and effective RFA treatment for the metastatic spinal tumor. Further investigation is necessary.
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