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Regeneration of rotator cuff using bioabsorbable scaffold without cultured cells

Research Project

Project/Area Number 22591655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKobe University

Principal Investigator

KOKUBU Takeshi  神戸大学, 大学院・医学研究科, 助教 (40403266)

Co-Investigator(Kenkyū-buntansha) NAGURA Issei  神戸大学, 医学研究科, 医学研究員 (00437485)
KUROSAKA Masahiro  神戸大学, 医学研究科, 教授 (70170115)
MIFUNE Yutaka  神戸大学, 医学部附属病院, 助教 (80608464)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肩腱板広範囲断裂 / 腱板再生 / スキャフォールド / PLG / electrospinning 法 / electrospinning法 / Poly(DL-lactide-co-glycolide)(PLG) / Poly (DL-lactide-co-glycolide) (PLG)
Research Abstract

The purpose of this study was to evaluate an application of poly (D-L-lactide-co-glycolide) (PLG) scaffold in a rabbit rotator cuff defect model. Histologically, spindle shaped cells were observed inside of the scaffold at 4 weeks postoperatively. At 8 weeks, the PLG scaffold had dissolved andbone formation was observed at the scaffold-bone interface. At 16 weeks, the scaffold-bone interface matured and expression of type II collagen was observed. Biomechanically, statistical difference of ultimate failure load was not seen between scaffold group and normal tendon after 8 weeks postoperatively. This PLG scaffold could be applied to bridge rotator cuff defect.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Regeneration of Rotator Cuff Tear Using ElectrospunPoly(d,l-Lactide-Co-Glycolide) Scaffolds in a Rabbit Model2012

    • Author(s)
      Inui A, Kokubu T, Mifune Y, Sakata R, Nishimoto H, Nishida K, Akisue T, Kuroda R, Satake M, Kaneko H, Fujioka H.
    • Journal Title

      Arthroscopy

      Volume: 28(12) Pages: 1790-1799

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ポリ乳酸・グリコール酸(PLG)スカフォールドを使用した家兎肩腱板再生の試み2012

    • Author(s)
      乾淳幸、国分毅、美舩泰、他
    • Journal Title

      肩関節

      Volume: 36(3) Pages: 913-916

    • NAID

      130002103562

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 人工吸収性材料による肩腱板の再生 家兎棘下筋腱による検討2012

    • Author(s)
      国分毅、乾淳幸、美舩泰、黒坂昌弘
    • Journal Title

      関節外科

      Volume: 31(7) Pages: 742-748

    • Related Report
      2012 Final Research Report
  • [Journal Article] Regeneration of rotator cuff tear using electrospun poly(d,l-Lactide-Co-Glycolide) scaffolds in a rabbit model.2012

    • Author(s)
      Inui A, Kokubu T, Mifune Y, et al.
    • Journal Title

      Arthroscopy

      Volume: 28(12) Issue: 12 Pages: 1790-9

    • DOI

      10.1016/j.arthro.2012.05.887

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 人工吸収性材料による肩腱板の再生 家兎棘下筋腱による検討2012

    • Author(s)
      国分毅、乾淳幸、美舩泰、黒坂昌弘
    • Journal Title

      関節外科

      Volume: 31(7) Pages: 742-8

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Application of layered poly (L-lactic acid) cell free scaffold in a rabbit rotator cuff defect model2011

    • Author(s)
      Inui A, Kokubu T, Fujioka H, Nagura I, Sakata R, Nishimoto H, Kotera M,Nishino T, Kurosaka M
    • Journal Title

      Sports Med Arthrosc Rehabil Ther Technol

      Volume: 3 Pages: 29-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of layered Poly (L-lactic acid) cell free scaffold in a rabbit rotatorcuff defect model2011

    • Author(s)
      Inui A
    • Journal Title

      Sports Med Arthrosc Rehabil Ther Technol

      Volume: 3(29)(Electronic) Issue: 1

    • DOI

      10.1186/1758-2555-3-29

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potency of double-layered Poly L-lactic Acid scaffold in tissue engineering of tendon tissue2010

    • Author(s)
      Inui A, Kokubu T, Makino T, Nagura I, Toyokawa N, Sakata R, Kotera M, Nishino T, Fujioka H, Kurosaka M
    • Journal Title

      Int Orthop.

      Volume: 34(8) Pages: 1327-32

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potency of double-layered Poly L-lactic Acid scaffold in tissue engineering of tendon tissue.2010

    • Author(s)
      Inui A, et al.
    • Journal Title

      International Orthopaedics

      Volume: 34(8) Pages: 1327-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリ乳酸グリコール酸(PLG)スキャフォールドを用いたウサギ肩腱板再生2011

    • Author(s)
      国分毅、名倉一成、美舩泰、黒坂昌弘
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] ポリ乳酸グリコール酸(PLG)シートを使用したウサギ肩腱板再生2011

    • Author(s)
      国分毅、名倉一成、美舩泰
    • Organizer
      第38回日本肩関節学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-07
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Regeneration of rotator cuff tear using electrospun poly (DL-lactide-coglycolide) (PLG) scaffolds in a rabbit model.2011

    • Author(s)
      Inui A, Kokubu T, Makino T, Nagura I,Kurosaka Met al.
    • Organizer
      57thAnnual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Long Beach, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Regeneration of rotator cuff tear using electrospun poly (DL-lactide-co-glycolide) (PLG) scaffolds in a rabbit model2011

    • Author(s)
      Inui A, et al.
    • Organizer
      2011 Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Long Beach, CA, (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potency of double layered PLLA scaffold in tissue engineering of tendon tissue.2010

    • Author(s)
      Kokubu T, Makino T, Inui A, Nagura I,Kurosaka Met al
    • Organizer
      7th Combined Meeting of the Orthopedic Research Societies.
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Potency of double layered PLLA scaffold in tissue engineering of tendon tissue2010

    • Author(s)
      Kokubu T, e t al.
    • Organizer
      7^<th> Combined Meeting of the Orthopedic Research Societies
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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