| Project/Area Number |
22591655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
KOKUBU Takeshi 神戸大学, 大学院・医学研究科, 助教 (40403266)
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| Co-Investigator(Kenkyū-buntansha) |
NAGURA Issei 神戸大学, 医学研究科, 医学研究員 (00437485)
KUROSAKA Masahiro 神戸大学, 医学研究科, 教授 (70170115)
MIFUNE Yutaka 神戸大学, 医学部附属病院, 助教 (80608464)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肩腱板広範囲断裂 / 腱板再生 / スキャフォールド / PLG / electrospinning 法 / electrospinning法 / Poly(DL-lactide-co-glycolide)(PLG) / Poly (DL-lactide-co-glycolide) (PLG) |
|---|
| Research Abstract |
The purpose of this study was to evaluate an application of poly (D-L-lactide-co-glycolide) (PLG) scaffold in a rabbit rotator cuff defect model. Histologically, spindle shaped cells were observed inside of the scaffold at 4 weeks postoperatively. At 8 weeks, the PLG scaffold had dissolved andbone formation was observed at the scaffold-bone interface. At 16 weeks, the scaffold-bone interface matured and expression of type II collagen was observed. Biomechanically, statistical difference of ultimate failure load was not seen between scaffold group and normal tendon after 8 weeks postoperatively. This PLG scaffold could be applied to bridge rotator cuff defect.
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