Regenerative medicine for cartilage, bone and ligament using growth factors mobilizing stem cell
| Project/Area Number |
22591656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUROSAKA Masahiro 神戸大学, 医学研究科, 教授 (70170115)
KUBO Seiji 神戸大学, 医学部附属病院, 助教 (30452494)
MATSUSHITA Takehiko 神戸大学, 医学部附属病院, 特定助教 (40467650)
MATSUMOTO Tomiyuki 神戸大学, 医学部附属病院, 助教 (50546588)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 幹細胞 / 再生医療 / 運動器 / 顆粒球コロニー刺激因子(G-CSF) / 骨 / 軟骨 / 靭帯 / 関節軟骨 / 靱帯 |
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| Research Abstract |
It has been reported that stem cell and multi-potent cells such as iPS cells, ES cells contribute to tissue regeneration. Granulocyte colony-stimulating factor (G-CSF）has important role recruiting stem cells. Stem cells contribute to fix injury of locomotorium (bone, joint, cartilage, ligament etc.).We hound that there were abundant vascular stem cells in injury site and G-CSF was one of the key factors to regenerate bone, cartilage and ligament.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue2012
Author(s)
MatsumotoT, Kubo S, Sasaki K, Kawakami Y, Oka S, Sasaki H, Takayama K, Tei K, Matsushita T, Mifune Y, Kurosaka M, Kuroda R
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Journal Title
Am J Sports Med.
Volume: 40(6)
Issue: 6
Pages: 1296-302
DOI
Related Report
Peer Reviewed
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[Journal Article] Local transplantation of granulocyte colony-stimulating factor-mobilized human peripheral blood mononuclear cells for unhealing bone fractures2012
Author(s)
Fukui T, Matsumoto T, Mifune Y, Shoji T, Kuroda T, Kawakami Y, Kawamoto A, Ii M, Kawamata S, Kurosaka M, Asahara T, Kuroda R
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Journal Title
Cell Transplant
Volume: 21(4)
Issue: 9
Pages: 707-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Local transplantation of G-CSF-mobilized CD34(+) cells in a patient with tibial nonunion: a case report2011
Author(s)
Kuroda R, Matsumoto T, Miwa M, Kawamoto A, Mifune Y, Fukui T, Kawakami Y, Niikura T, Lee SY, Oe K, Shoji T, Kuroda T, Horii M, Yokoyama A, Ono T, Koibuchi Y, Kawamata S, Fukushima M, Kurosaka M, Asahara T
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Journal Title
Cell Transplant
Volume: 20(9)
Issue: 9
Pages: 1491-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Bone regeneration properties of granulocyte colony-stimulating factor via neovascularization and osteogenesis.2010
Author(s)
Ishida K, Matsumoto T, Sasaki K, Mifune Y, Tei K, Kubo S, Matsushita T, Takayama K, Akisue T, Tabata Y, Kurosaka M, Kuroda R.
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Journal Title
Tissue Eng Part A
Volume: 16(10)
Issue: 10
Pages: 3271-84
DOI
Related Report
Peer Reviewed
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