Anti-tumor effect of doxorubicin with bubble liposome and ultrasound
| Project/Area Number |
22591662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ZEMMYO Michihisa 鹿児島大学, 医学部, 助教 (10289465)
KOMIYA Setsuro 鹿児島大学, 医学部, 教授 (30178371)
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| Research Collaborator |
UENO Yoshinori 鹿児島大学, 医学部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 骨軟部肉腫 / 化学療法 / 抗癌剤 / 有害事象 / 超音波 / マイクロバブル / 骨肉腫 / ドラッグデリバリーシステム / デリバリーシステム |
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| Research Abstract |
We constructed a drug delivery system by concomitant use of ultorasound with doxorubicin, a key drug in the chemotherapy of osteosarcoma, and demonstrated both in vitroand in vivothat this drug delivery system markedly inhibited the proliferation of osteosarcoma cells and pulmonary metastasis.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy.2012
Author(s)
Hiroko Nagao, Takao Setoguchi, Sho Kitamoto, Yasuhiro Ishidou, Satoshi Nagano, Masahiro Yokouchi, Masahiko Abematsu, Naoya Kawabata, Shingo Maeda, Suguru Yonezawa, Setsuro Komiya
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Journal Title
PLoS ONE
Volume: 7(7)
Issue: 7
Pages: e39268-e39268
DOI
Related Report
Peer Reviewed
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