Analysis of response mechanism of osteoblast by physical stimulation -mechanical stress and electrical stimulation
| Project/Area Number |
22591667
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIM Wook-cheol 京都府立医科大学, 大学院・医学研究科運動器機能再生外科学(整形外科学教室), 准教授 (50244603)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞・組織 / シグナル伝達 / 生体分子 / 再生医学 / 医療・福祉 |
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| Research Abstract |
We conducted an alternating current electrical stimulation to theosteoblastic cell line MC3T3-E1, and examined the phosphorylation of MAPK(mitogen-activated protein kinase) as an indicator . By the AC electrical stimulation for 20 min, phosphorylation of ERK and p38 (MAPK) was increased significantly than thenon-stimulated group. Part of the response mechanism for electrical stimulation of osteoblasts been elucidated, the establishment of stimulus conditions and methods of useful mechanical stress can be expected.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 生体交流電気刺激の基礎と臨床2011
Author(s)
金 郁〓,吉田隆司,山田尚武,西田敦士,河本浩栄,平島淑子,久保俊一
Organizer
第38回日本生体電気・物理刺激研究会
Place of Presentation
文京区
Year and Date
2011-03-05
Related Report
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