| Project/Area Number |
22591675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
SASYO Takahisa 千葉大学, 大学院・医学研究院, 講師 (20312952)
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| Co-Investigator(Kenkyū-buntansha) |
TSURUOKA Hiroaki 千葉大学, 大学院・医学研究院, 大学院生 (30533327)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Masahiko 千葉大学, 大学院医学研究院, 大学院生
IKEGAWA Naoshi 千葉大学, 大学院・医学研究院, 大学院生 (70466697)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 軟骨損傷 / 軟骨修復 / 軟骨部分損傷 / 遺伝子発現 / TGFベータ / Smad3 / マイクロアレー / TGF-beta / 前初期遺伝子(immediate early genes) |
|---|
| Research Abstract |
Partial thickness cartilage injury (PTI) will not heal spontaneously in post natal animals. However we have established an animal model that shows spontaneous repairof PTCD using 3 week-old rats. Comparing gene expression profile of injured cartilage of this model with that of 16 week-old rat cartilage where repair will not occur, genes required for spontaneous cartilage repair were identified. As a result, the importance of Smad3 that transmit TGF-beta signal was elucidated.
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