Detection of genes required for spontaneous cartilage repair
| Project/Area Number |
22591675
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
SASYO Takahisa 千葉大学, 大学院・医学研究院, 講師 (20312952)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSURUOKA Hiroaki 千葉大学, 大学院・医学研究院, 大学院生 (30533327)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAITO Masahiko 千葉大学, 大学院医学研究院, 大学院生
IKEGAWA Naoshi 千葉大学, 大学院・医学研究院, 大学院生 (70466697)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 軟骨損傷 / 軟骨修復 / 軟骨部分損傷 / 遺伝子発現 / TGFベータ / Smad3 / マイクロアレー / TGF-beta / 前初期遺伝子(immediate early genes) |
|---|
| Research Abstract |
Partial thickness cartilage injury (PTI) will not heal spontaneously in post natal animals. However we have established an animal model that shows spontaneous repairof PTCD using 3 week-old rats. Comparing gene expression profile of injured cartilage of this model with that of 16 week-old rat cartilage where repair will not occur, genes required for spontaneous cartilage repair were identified. As a result, the importance of Smad3 that transmit TGF-beta signal was elucidated.
|
Report
(4 results)
Research Products
(16 results)
-
[Journal Article] Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model2012
Author(s)
Saito M, Sasho T, Yamaguchi S, Ikegawa N, Akagi R, Muramatsu Y, Mukoyama S, Ochiai N, Nakamura J, Nakagawa K, Nakajima A, Takahashi K
-
Journal Title
Osteoarthritis and Cartilage
Volume: 20(12)
Issue: 12
Pages: 1574-82
DOI
Related Report
Peer Reviewed
-
[Journal Article] Maturation-dependent spontaneous healing of partial thickness cartilage defects in infantile rats2011
Author(s)
Tsuruoka H, Sasho T, Yamaguchi S, Ikegawa N, Saito M, Akagi R, Ochiai N, Nakagawa K, Nakajima A, Fallouh L, Takahashi K.
-
Journal Title
Cell Tissue Res
Volume: 346
Issue: 2
Pages: 263-271
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Difference in Age-Dependent Gene Expressions in the Early Stage of Partial-Thickness Articular Cartilage Defect in Rat2011
Author(s)
Ikegawa N, Sasho T, Akagi R, Saito M, Tsuruoka H, Yamaguchi S, Matsuki K, Nakagawa K, Takahashi K.
Organizer
Orthopaedic Research Society 2011
Place of Presentation
Long Beach, CA, USA
Year and Date
2011-03-15
Related Report
-
-
-
