Molecular mechanism of cartilage repair using tenascin C and application for treatment
Project/Area Number |
22591684
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUDO Akihiro 三重大学, 大学院・医学系研究科, 教授 (60196904)
TUJII Masaya 三重大学, 大学院・医学系研究科, 助教 (40444442)
YOSHIDA Toshimichi 三重大学, 大学院・医学系研究科, 教授 (80166959)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 骨・軟骨代謝学 / テネイシンC / 軟骨修復 / 変形性関節症 / 細胞外基質 / 関節 / テネイシン / cartilage / tenascin C / proteoglycan / repair / matrix |
Research Abstract |
We used tenascin-C (TNC) to enhance cartilage repair. The treatment of human articular chondrocytes with TNC accelerated chondrocyte proliferation andstimulation of proteoglycan synthesis. Cartilage defects were created in the murineknee. Proteoglycan and type II collagen rich cartilage was regenerated after administration of TNC. Local administration of TNC could promote the cartilage repair.
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Report
(4 results)
Research Products
(246 results)
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[Journal Article] The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group.2013
Author(s)
Hasegawa M, Horiki N, Tanaka K, Wakabayashi H, Tano S, Katsurahara M, Uchida A, Takei Y, Sudo A
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Journal Title
Mod Rheumatol
Volume: in press
Pages: 1172-1178
DOI
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Peer Reviewed
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[Journal Article] Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction2012
Author(s)
Sato A, Hiroe M, Akiyama D, Hikita H,Nozato T, Hoshi T, Kimura T, Wang Z, Sakai S, Imanaka-Yoshida K, Yoshida T, Aonuma K
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Journal Title
J Card Fail
Volume: 18
Pages: 480-486
Related Report
Peer Reviewed
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[Journal Article] Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux.2012
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A.
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Journal Title
Int J Hematol
Volume: 95
Issue: 2
Pages: 160-166
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction.2012
Author(s)
Sato A, Hiroe M, Akiyama D, Hikita H, Nozato T, Hoshi T, Kimura T, Wang Z, Sakai S, Imanaka-Yoshida K, Yoshida T, Aonuma K.
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Journal Title
J Card Fail
Volume: 18
Issue: 6
Pages: 480-486
DOI
Related Report
Peer Reviewed
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[Journal Article] The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone2012
Author(s)
Asanuma K, Wakabayashi H, Okamoto T, Asanuma Y, Akita N, Yoshikawa T, Hayashi T, Matsumine A, Uchida A, Sudo A
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Journal Title
Breast Cancer
Volume: (Epub ahead of print)
NAID
Related Report
Peer Reviewed
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[Journal Article] Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux2012
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
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Journal Title
Int J Hematol
Volume: 95(2)
Pages: 160-6
NAID
Related Report
Peer Reviewed
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[Journal Article] Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement2011
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Ando H, Oshima S, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
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Journal Title
Int Jhematol
Volume: 94
Pages: 355-360
NAID
Related Report
Peer Reviewed
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
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Journal Title
Anticancer Res
Volume: 31(12)
Pages: 4163-8
Related Report
Peer Reviewed
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[Journal Article] Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement2011
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Ando H, Oshima S, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
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Journal Title
Int J Hematol
Volume: 94(4)
Pages: 355-60
NAID
Related Report
Peer Reviewed
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[Journal Article] Japanese Musculoskeletal Oncology Group.Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur2011
Author(s)
Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A
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Journal Title
J Surg Oncol
Volume: 103(3)
Issue: 3
Pages: 257-63
DOI
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Peer Reviewed
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[Journal Article] 人工関節置換術後のフォンダパリヌクス濃度のモニター2011
Author(s)
和田英夫, 天満大志, 藤原圭人, 小川真央, 池尻誠, 松本剛史, 片山直之, 登勉, 辻明宏, 太田覚史, 土肥薫, 山田典一, 中村真潮, 伊藤正明, 吉田格之進, 長谷川正裕, 須藤啓広
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Journal Title
心臓
Volume: 43(7)
Pages: 1039-1040
NAID
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[Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice2010
Author(s)
Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 298
Pages: 1072-1078
Related Report
Peer Reviewed
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[Journal Article] The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group
Author(s)
Hasegawa M, Horiki N, Tanaka K, Wakabayashi H, Tano S, Katsurahara M, Uchida A, Takei Y, Sudo A
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Matsui Y, Hasegawa M, Ikemura S, Iino T, Imanaka-Yoshida K, Yoshida T, Sudo A2013
Author(s)
Matsui Y, Hasegawa M, Ikemura S, Iino T, Imanaka-Yoshida K, Yoshida T, Sudo A
Organizer
Orthopaedic Research Society 2013 Annual Meeting
Place of Presentation
San Antonio
Year and Date
2013-01-29
Related Report
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[Presentation] Hasegawa M, Tanaka K, Horiki N, Wakabayashi H, Uchida A, Takei Y, Sudo A2012
Author(s)
Hasegawa M, Tanaka K, Horiki N, Wakabayashi H, Uchida A, Takei Y, Sudo A
Organizer
Combined 33rd SICOT & 17th PAOA Orthopaedic World Conference
Place of Presentation
Dubai
Year and Date
2012-10-30
Related Report
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[Presentation] Hasegawa M, Ikemura S, Iino T, Segawa T, Maeda M, Yoshida T, Sudo A2011
Author(s)
Hasegawa M, Ikemura S, Iino T, Segawa T, Maeda M, Yoshida T, Sudo A
Organizer
2011 Annual Meeting of the Orthopaedic Research Society
Place of Presentation
Long Beach
Year and Date
2011-01-16
Related Report
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