| Project/Area Number |
22591685
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
TOMITA Tetsuya 大阪大学, 医学系研究科, 寄附講座准教授 (30283766)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Hideki 大阪大学, 大学院・・医学系研究科, 教授 (60191558)
IWAI Kazuhiro 大阪大学, 大学院・医学系研究科, 教授 (60252459)
KUNUGIZA Yasuo 大阪大学, 大学院・医学系研究科, 助教 (60507193)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | arthritis / inflammation / NF kappa B / LUBAC / 関節リウマチ / NF-kB |
|---|
| Research Abstract |
In this study, we investigated the expression of LUBAC in patients with rheumatoid arthritis. OA samples were used as control in this study. Both in RA and OA synovium, the expression of LUBAC（HOIP／HOIL-1L）was confirmed using immuno-histochemistry. The expression in RA was up-regulated compared to OA. Furthermore, the expression of LUBAC（HOIP／HOIL-1L）was confirmed in the serum of both RA and OA patients. The expression in RA was significantly higher compared to OA. The results in this study suggested that the expression of HOIP／HOIL-1L may play an important role in the activation pathway of NF-kB in patients with rheumatoid arthritis.
|
