| Project/Area Number |
22591686
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
OOHASHI Toshitaka 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (50194262)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Keiichiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80284058)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOMATSU Naoki 滋賀医科大学, 医学部, 准教授 (30253008)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 関節軟骨 / プロテオグリカン / MRI / マトリックスメタロプロテアーゼ / 分子標的化 / 関節 / 軟骨 / 画像解析 / 造影剤 / X線 / 生体イメージング / 診断 |
|---|
| Research Abstract |
Current research aimed to develop a new multifunctional nano-probes for diagnosis and treatment of osteoarthritis, which will increase according to the acceleration of demographic aging. We could demonstrate the effect of cartilage-specific contrast agent, octaarginine peptide conjugated with DOTA-Gd, in ex vivo and in vivo experiments of rabbit knee joints. While R8-N-TIMP3, designed as a cartilage protective agent, did not show sufficient protective effect in a mouse model of rheumatoid arthritis although it showed in ex vivo tissue culture experiments. Further study is necessary after a prolonged expression of R8-NTIMP-3 in the arthritic knee joints.
|
