| Project/Area Number |
22591692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KIDA Yoshikuni 東京慈恵会医科大学, 医学部, 助教 (90328310)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Mitsuru 東京慈恵会医科大学, 医学部, 准教授 (50301528)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 骨質評価法 / AGEs / ペントシジン / コラーゲン / 非侵襲的骨質評価法 / AGEs架橋 / 骨折リスク |
|---|
| Research Abstract |
Degradation of “bone quality”, a marker of bone strength different from bone density, has become available for evaluation in everyday clinical practice. The possibility was validated by the results of a non-invasive analysis of bone quality in which blood, urine, skin and bone samples from the same individual were collected and compared with those from other individuals for accumulation of advanced glycation end products (AGEs, cross-linking pentosidine). Higher AGEs levels were well correlated with two non-invasive parameters: estimated glomerular filtration rate and urine pentosidine concentration that may be therefore considered as indirect but useful markers of bone quality breakdown.
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