Mechanism of neurotoxicity by anesthetics in the developing brain-Effect of hypercapnia
| Project/Area Number |
22591699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hokkaido University |
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Principal Investigator |
MORIMOTO Yuji 北海道大学, 大学院・医学研究科, 教授 (00250457)
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Kaori 北海道大学, 病院, 医員 (50374468)
TSURUGA Kenkichi 北海道大学, 病院, 助教 (50399896)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 麻酔薬 / 神経毒性 / 幼弱期 / 高二酸化炭素血症 / 幼弱脳 / 麻醉薬 |
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| Research Abstract |
To investigate the possible long-term consequences of neonatal exposure to hypoxic hypercapnia regarding learning ability, we investigated the effect of neonatal hypoxic hypercapnia on later functions in the hippocampus. Neonatal rat pups (postnatal day 7; P7) were exposed to a high concentration of carbon dioxide (CO2; 13%) for 2 or 4 h. Exposure to CO2 in P7 rat pups disrupted later learning acquisition, as assessed in 10-week-old adult rats subjected to a Morris water maze test. Induction of long-term potentiation (LTP) in the synapses of the hippocampal CA1 area was also impaired, whereas the paired-pulse responses of population spikes exhibited a significant increase in CO2-exposed rats. Such long-lasting modifications in hippocampal synaptic plasticity may contribute to the learning impairments associated with perinatal hypoxic hypercapnia and acidosis.
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Report
(4 results)
Research Products
(18 results)
