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Mechanism of neurotoxicity by anesthetics in the developing brain-Effect of hypercapnia

Research Project

Project/Area Number 22591699
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHokkaido University

Principal Investigator

MORIMOTO Yuji  北海道大学, 大学院・医学研究科, 教授 (00250457)

Co-Investigator(Kenkyū-buntansha) TACHIBANA Kaori  北海道大学, 病院, 医員 (50374468)
TSURUGA Kenkichi  北海道大学, 病院, 助教 (50399896)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords麻酔薬 / 神経毒性 / 幼弱期 / 高二酸化炭素血症 / 幼弱脳 / 麻醉薬
Research Abstract

To investigate the possible long-term consequences of neonatal exposure to hypoxic hypercapnia regarding learning ability, we investigated the effect of neonatal hypoxic hypercapnia on later functions in the hippocampus. Neonatal rat pups (postnatal day 7; P7) were exposed to a high concentration of carbon dioxide (CO2; 13%) for 2 or 4 h. Exposure to CO2 in P7 rat pups disrupted later learning acquisition, as assessed in 10-week-old adult rats subjected to a Morris water maze test. Induction of long-term potentiation (LTP) in the synapses of the hippocampal CA1 area was also impaired, whereas the paired-pulse responses of population spikes exhibited a significant increase in CO2-exposed rats. Such long-lasting modifications in hippocampal synaptic plasticity may contribute to the learning impairments associated with perinatal hypoxic hypercapnia and acidosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results)

  • [Journal Article] Neonatalexposuretohighconcentrationofcarbondi oxideproducespersistentlearningdeficitswith impaired hippocampal synaptic plasticity2013

    • Author(s)
      Kaori Tachibana, Toshikazu Hashimoto, Koichi Takita, Ryoko Ito, Rui Kato, Yuji Morimoto
    • Journal Title

      Brain Research

      Volume: 1507 Pages: 83-90

    • DOI

      10.1016/j.brainres.2013.02.045

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatalexposuretohighconcentrationofcarbondioxideproducespersistentlearningdeficitswithimpaired hippocampal synaptic plasticity2013

    • Author(s)
      Kaori Tachibana
    • Journal Title

      Brain Research

      Volume: 1507 Pages: 83-90

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood2012

    • Author(s)
      Kaori Tachibana, Toshikazu Hashimoto, Rui Kato, Yosuke Uchida, Ryoko Ito, Koich Takita, Yuji Morimoto
    • Journal Title

      Pediatric Anesthesia

      Volume: 22 Pages: 13-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood2012

    • Author(s)
      Kaori Tachibana
    • Journal Title

      Pediatric Anesthesia

      Volume: 22 Pages: 13-19

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-lasting effects of neonatal pentobarbital administration on spatial learning and hippocampal synaptic plasticity2011

    • Author(s)
      K.Tachibana, et al
    • Journal Title

      Brain Research

      Volume: 1, 388 Pages: 69-76

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 麻酔は脳にとって"悪"なのか:幼若ラットの海馬機能に対する全身麻酔薬の長期的な障害作用2012

    • Author(s)
      加藤類
    • Organizer
      日本臨床麻酔学会
    • Place of Presentation
      ビッグパレット福島
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 麻酔は脳にとって"悪"なのか:幼若動物での麻酔薬による神経毒性の評価において麻酔薬暴露時の血液ガス異常は無視できるか?2012

    • Author(s)
      橘かおり
    • Organizer
      日本臨床麻酔学会
    • Place of Presentation
      ビッグパレット福島
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] The Effect of Hypercapnea and Oxygen Concentration on Neuroapoptosis in Neonatal Rat Brain2012

    • Author(s)
      Yosuke Uchida
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      convention center, Washington DC, USA
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Electrophysiological Impairments Caused by Sevoflurane Exposure Depended on Developmental Period in Rat2012

    • Author(s)
      Rui Kato
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      convention center, Washington DC, USA
    • Year and Date
      2012-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 新生ラットモデルにおける低酸素・高二酸化負荷による成長後の神経学的予後の検討2012

    • Author(s)
      橘かおり
    • Organizer
      日本神経麻酔・集中研究会
    • Place of Presentation
      岡山大学、岡山
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 幼若ラットの海馬機能に対する全身麻酔薬の長期的な障害作用2012

    • Author(s)
      加藤類
    • Organizer
      第32回日本臨床麻酔学会
    • Place of Presentation
      ビッグパレット福島(郡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 幼若動物での麻酔薬にのる神経毒性の評価において麻酔薬暴露時の血液ガス異常は無視できるか?2012

    • Author(s)
      橘かおり
    • Organizer
      第32回日本臨床麻酔学会
    • Place of Presentation
      ビッグパレット福島(郡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Electrophysiological Impairments Caused by Sevoflurane Exposure Depended on Developmental Period in Rat2012

    • Author(s)
      Rui Kato
    • Organizer
      American society of Anesthesiologists
    • Place of Presentation
      Convention Center(Washington, D.C., USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Effect of Hypercapnea and Oxygen Concentration on Neuroapoptosis in Neonatal Rat Brain2012

    • Author(s)
      Yosuke Uchida
    • Organizer
      American society of Anesthesiologists
    • Place of Presentation
      Convention Center(Washington, D.C., USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム幼弱脳に対する麻酔薬の神経毒性:幼弱脳に対する麻酔薬の神経毒性-概論2011

    • Author(s)
      森本裕二
    • Organizer
      日本麻酔科学会学術集会
    • Place of Presentation
      ポートピアホテル、神戸
    • Year and Date
      2011-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 幼弱脳に対する麻酔薬の神経毒性:幼若動物でみられる全身麻酔による神経毒性に、呼吸抑制による影響はないのだろうか?2011

    • Author(s)
      橘かおり
    • Organizer
      日本麻酔科学会学術集会
    • Place of Presentation
      ポートピアホテル、神戸
    • Year and Date
      2011-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 幼弱脳に対する麻酔薬の神経毒性:幼弱脳に対する麻酔薬の神経毒性-概論-2011

    • Author(s)
      森本裕二
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      ポートピアホテル(兵庫)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 麻酔薬は脳にとってフレネミーか?2010

    • Author(s)
      森本裕二
    • Organizer
      第56回 日本麻酔科学会関西支部学術集会
    • Place of Presentation
      大阪国際交流センター 招待講演
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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