Sleep and general anesthesia : maintaining patient safety and improving the QOL during perioperative period

• Project/Area Number: 22591701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hirosaki University
• Principal Investigator: YOSHIDA Hitoshi 弘前大学, 医学(系)研究科(研究院), 講師 (00374843)
• Co-Investigator(Kenkyū-buntansha): KUSHIKATA Tetsuya 弘前大学, 医学部附属病院, 講師 (80250603) ; HIROTA Kazuyoshi 弘前大学, 医学(系)研究科(研究院), 教授 (20238413)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 脳・神経 / 全身麻酔 / 睡眠 / 脳波 / 内因性睡眠物質

Research Abstract

We examined to elucidate the relationship between normal sleep and general anesthesia focused on the role of cytokine and adenosine in the brain. Thiopental-induced anesthesia time altered according to sleep propensity. Cerebral cortical adenosine can play a role to regulate the electroencephalogram activity during general anesthesia.