The analysis of the mechanisms by which volatile anesthetics and propofol induce apoptosis of immune cells.

• Project/Area Number: 22591702
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tohoku University
• Principal Investigator: KUROSAWA Shin 東北大学, 病院, 准教授 (60272043)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 麻酔学 / 麻酔科学

Research Abstract

In this study, volatile anesthetics induced thymocyte apoptosis and reduced mitochindrial membrane potential in thymocytes dose- and time-dependently. In addition, the reduction of mitochondrial membrane potential preceded the induction of thymocyte apoptosis. Probably, reduction of mitochondrial membrane potential in thymocytes is one of the initial events.

Research Products

• [Journal Article] Anesthesia in patients with cancer disorders (2012)
  • Author(s): Shin Kurosawa
  • Journal Title: Current Opinion in Anesthesiology Volume: Vol.25-No.3 Issue: 3 Pages: 376-384
  • DOI: 10.1097/aco.0b013e328352b4a8
  • Peer Reviewed
• [Journal Article] Impact of changes of positive end-expiratory pressure on functional residual capacity at low tidal volume ventilation during general anesthesia (2012)
  • Author(s): Daizo Satoh、Shin Kurosawa、Wakaba Kirino、Toshihiro Wagatsuma、Yutaka Ejima、AkikoYoshida、Hiroaki Toyama、Kei Nagaya
  • Journal Title: J. Anesthesia Volume: Vol.26-No.5 Issue: 5 Pages: 664-669
  • DOI: 10.1007/s00540-012-1411-9
  • NAID: 10031123487
  • Peer Reviewed
• [Journal Article] Overexpression of Delayed Rectifier K+ Channels Promotes In situProliferation ofLeukocytes in Rat Kidneys with Advanced Chronic Renal Failure (2012)
  • Author(s): Itsuro Kazama、Yoshio Maruyama, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Shin Kurosawa
  • Journal Title: International Journal of Nephrology Volume: 1 Pages: 1-8
  • DOI: 10.1155/2012/581581
  • Peer Reviewed
• [Journal Article] Surgical stress increases circulating endothelial microparticles in elderly (2012)
  • Author(s): T.Takahashi、H.Kubo、N.Fujino、T.Suzuki、 C.Ota 、 M.Yamada 、 M.Yamada 、 S.Suzuki 、 S.Kurosawa
  • Journal Title: Anaesthesia and Intensive Care Volume: Vol.40-No.5 Pages: 899-902
  • Peer Reviewed
• [Journal Article] Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility (2012)
  • Author(s): Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H.
  • Journal Title: Thorax Volume: 67 Issue: 12 Pages: 1067-1074
  • DOI: 10.1136/thoraxjnl-2011-201395
  • Peer Reviewed
• [Journal Article] Compensatory Thrombopoietin Production from the Liver and Bone Marrow Stimulates Thrombopoiesis of Living Rat Megakaryocytes in Chronic Renal Failure (2012)
  • Author(s): Etsuro Kazama、Yasuhiro Endo、Hiroaki Toyama 、 Yutaka Ejima 、 Shin Kurosawa 、 Yoshimichi Murata、Mitsunobu Matsubara、Yoshio Maruyama
  • Journal Title: Nephron Extra Volume: Vol.1 Issue: 1 Pages: 147-156
  • DOI: 10.1159/000333018
  • Peer Reviewed
• [Journal Article] Comparison of actual tidal volume in neonatal lung model volume control ventilation using three ventilators (2012)
  • Author(s): Hiroaki Toyama、Yasuhiro Endo、Yutaka Ejima、Mitsunobu Matsubara、Shin Kurosawa
  • Journal Title: Anaesthesia and Intensive Care Volume: Vol.39-No.4 Pages: 599-606
  • Peer Reviewed
• [Journal Article] Impaired endothelial progenitor cell mobilization and colony-forming capacityin chronic obstructive pulmonary disease (2012)
  • Author(s): Toru Takahashi、Satoshi Suzuki、Hiroshi Kubo、Matsuo Yamaya、Shin Kurosawa、Masato Kato
  • Journal Title: Respirology Volume: Vol.16-No.4 Issue: 4 Pages: 680-687
  • DOI: 10.1111/j.1440-1843.2011.01959.x
  • Peer Reviewed
• [Journal Article] 揮発性吸入麻酔薬とリンパ球アポトーシス (2012)
  • Author(s): 西野涼、黒澤伸
  • Journal Title: Anesthesia 21 century Volume: Vol.14-No.1 Pages: 4-10
• [Journal Article] 麻酔管理と長期予後周術期管理と免疫機能 (2012)
  • Author(s): 黒澤伸
  • Journal Title: Anesthesia 21 Century Volume: Vol.12-No.3 Pages: 12-21
• [Journal Article] Higher fraction of inspired oxygen in anesthesia induction does not affect functional residual capacity reduction after intubation: a comparative study of higher and lower oxygen concentration. (2012)
  • Author(s): Akihiro Kanaya
  • Journal Title: Journal of Anesthesia Volume: 26 Issue: 3 Pages: 1-8
  • DOI: 10.1007/s00540-012-1547-7
  • Peer Reviewed
• [Journal Article] Surgical stress increases circulating endothelial microparticles in elderly. (2012)
  • Author(s): Toru Takahashi
  • Journal Title: Anaesthesia and Intensive Care Volume: 40 Pages: 899-902
  • Peer Reviewed
• [Journal Article] Remifentanil use for cesarean section in a patient with intracranial re-ruptured arteriovenous malformation (2012)
  • Author(s): Eiko Onishi
  • Journal Title: Journal of Anesthesia Volume: 26 Issue: 2 Pages: 275-279
  • DOI: 10.1007/s00540-011-1295-0
  • Peer Reviewed
• [Journal Article] 揮発性吸入麻酔薬とリンパ球アポトーシス (2012)
  • Author(s): 西野涼、黒澤伸
  • Journal Title: Anesthesia 21 Century Volume: 14 Pages: 4-10
• [Journal Article] Comparison of actual tidal volume in neonate lung model volume control ventilation using three ventilators (2011)
  • Author(s): Hiroaki Toyama, Shin Kurosawa
  • Journal Title: Anaesthesia and Intensive Care Volume: 39 Pages: 599-606
  • Peer Reviewed
• [Presentation] Thevolatile anesthetics isoflurane and sevoflurane affect glucose-stimulated insulin secretion in the pancreatic beta cell line MIN6 (2012)
  • Author(s): Kengo Suzuki、Hiroki Daijo、Shinichi Kai、 Tomonori Matsuyama 、 Shin Kurosawa 、 Kazuhiko Fukuda 、 Kiichi Hirota
  • Organizer: American society of Anesthesiologists Annual Meeting
  • Place of Presentation: Washington, DC(米国)
  • Year and Date: 2012-10-15
• [Presentation] Effects of intraoperative glucose and amino acid administration on energy requirement of patients during general anesthesia (2012)
  • Author(s): Tomoko Takahashi
  • Organizer: American society of Anesthesiologists
  • Place of Presentation: Washington, D.C. 米国
• [Presentation] Low incidence of emergence agitation in children after propofol anesthesia as compared with sevoflurane: A meta-analysis of randomized controlled trials. (2012)
  • Author(s): Akihiro Kanaya
  • Organizer: American society of Anesthesiologists
  • Place of Presentation: Washington, D.C. 米国
• [Presentation] The volatile anesthetics isoflurane and sevoflurane affect glucose-stimulated insulin secretion in the pancreatic beta cell line MIN6 (2012)
  • Author(s): Kengo Suzuki
  • Organizer: American society of Anesthesiologists
  • Place of Presentation: Washington, D.C. 米国
• [Presentation] 伸免疫能と麻酔管理 (2011)
  • Author(s): 黒澤
  • Organizer: 第31回日本臨床麻酔学会
  • Place of Presentation: 那覇
  • Year and Date: 2011-11-04
• [Presentation] 免疫能と麻酔管理 (2011)
  • Author(s): 黒澤伸
  • Organizer: 日本臨床麻酔学会第31回学術集会
  • Place of Presentation: 那覇(招待講演)
  • Year and Date: 2011-11-04
• [Presentation] Thoracic Surgery-induced Increase in Circulating Endothelial Microparticle Release in Elderly Patients (2011)
  • Author(s): Toru Takahashi、Hiroshi Kubo、Satoshi Suzuki 、 Shin Kurosawa
  • Organizer: American Society ofAnesthesiologists Annual Meeting
  • Place of Presentation: Chicago(米国)
  • Year and Date: 2011-10-19
• [Presentation] Differential Role of Prostaglandin E-type Receptors in Activation of Hypoxia-inducible Factor 1by Prostaglandine E1 in Vascular-derived Cell under Non-hypoxic Conditions (2011)
  • Author(s): Kengo Suzuki、Satoshi Takabuchi、Hiroki Daijo、Shinichi Kai、Tomonori Matsuyama、 Shin Kurosawa
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: Chicago(米国)
  • Year and Date: 2011-10-19
• [Presentation] Propofol Promotes Gulucocorticoids-induced Apoptosis of Murine Thymocytes in Vitro (2011)
  • Author(s): Noriko Toda、Shin Kurosawa、Kengo Suzuki、Wakaba Kirino 、 Yuko Saito
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: Chicago(米国)
  • Year and Date: 2011-10-18
• [Presentation] 揮発性吸入麻酔薬による免疫細胞毒性の解析ー揮発性吸入麻酔薬はマウス胸腺細胞のミトコンドリア膜電位を低下させ、アポトーシスを誘導する (2011)
  • Author(s): 黒澤伸
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-20
• [Presentation] プロポフォールはマウス胸腺細胞のデキサメタゾン誘導性アポトーシスを増強する (2011)
  • Author(s): 戸田法子、黒澤伸、齋藤浩二、吾妻俊弘、亀山良亘、小野寺尚子
  • Organizer: 日本麻酔科学会58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-20
• [Presentation] 揮発性吸入麻酔薬による免疫細胞毒性の解析 (2011)
  • Author(s): 黒澤伸
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] Endothelial Progenitor Cell Mobilization Was Impaired in Patients with Neoadjuvant Chemotherapy (2010)
  • Author(s): Toru Takahashi、Satoshi Suzuki、Shin Kurosawa、 Masato Kato、Hiroshi Kubo
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego(米国)
  • Year and Date: 2010-10-19
• [Presentation] Volatile Anesthetics Promote Glucocorticoid-Induced Apoptosis of Murine Thymocytes In Vitro (2010)
  • Author(s): Noriko Toda、Shin Kurosawa、Toshihiro Wagatsuma、Hiroaki Toyama、Yutaka Ejima
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego(米国)
  • Year and Date: 2010-10-17
• [Presentation] Volatile Anesthetics Promote Glucocorticoid-induced Apoptosis of Murine Thymocytes In Vitro (2010)
  • Author(s): 黒澤伸
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: アメリカ合衆国サンジエゴ市
  • Year and Date: 2010-10-17
• [Presentation] 揮発性吸入麻酔薬はデキサメタゾンによるマウス胸腺細胞のアポトーシスを増強する (2010)
  • Author(s): 戸田法子、黒澤伸、吾妻俊弘、齋藤浩二、吉田明子、長谷川淳一
  • Organizer: 第57回日本麻酔科学会学術集会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Book] 呼吸器研修ノート (2011)
  • Author(s): 渋津雅和、黒澤伸
  • Publisher: 診断と治療社