Neuroprotective effects of a Rho-kinase inhibitor after transient spinal cord ischemia in rats
| Project/Area Number |
22591703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOYAGI Toru 秋田大学, 医学部, 講師 (30302277)
KIMURA Tetsu 秋田大学, 医学部, 講師 (00312702)
梅原 志乃 秋田大学, 医学部, 助教 (40375291)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 虚血性脊髄傷害 / Rhoキナーゼ阻害薬 / ファスジル / 虚血前投与 / 脊髄前角細胞 / 脊髄白質障害 / 下肢運動欠損スコア |
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| Research Abstract |
Fasudil, a Rho-kinase inhibitor, has been reported to provide neuroprotective effects in several cerebral ischemia models, and we have also reported that fasudil attenuated neuronal injury in a rat transient cerebral ischemia-reperfusion model. We investigated whether fasudil 10 mg/kg provide the neuroprotective effects in a rat transient spinal cord ischemia-reperfusion model in terms of neurologic and histologic outcomes. Fasudil improved the histologic and neurologic outcomes on the 7th day and 14th day after ischemia.
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Report
(4 results)
Research Products
(8 results)
