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Modification of general anesthetic actions in hippocampus of the Alzheimer-type dementia model mice

Research Project

Project/Area Number 22591704
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Toyama

Principal Investigator

HIROTA Koki  富山大学, 大学院医学薬学研究部(医学), 准教授 (30218854)

Co-Investigator(Renkei-kenkyūsha) SASAKI Rika  富山大学, 大学院医学薬学研究部(医学), 助教 (10345572)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords認知症 / アルツハイマー病 / 海馬 / シナプス電位 / GABA / 全身麻酔薬 / 全身麻酔 / セボフルラン / 疾患モデルマウス / 抑制性シナプス伝達 / 再取り込み / 認知症モデルマウス
Research Abstract

Clinical anesthesiologists have an increasing opportunity to anesthetize elderly patients with dementia. In order to investigate whether the senile dementia modifies the anesthetic actions in the central nervous systems, we have studied effects of general anesthetics on the hippocampal synaptic transmission in the senescence-accelerated mice (SAM-P8 and SAM-R1). The characteristic feature of SAM-P8 mouse shows Alzheimer-type deficits in learning and memory, whereas SAM-R1 mouse has no neurological impairment. Field population spikes of CA1 pyramidal neurons were elicited, following the activation of recurrent inhibition. The pre-pulses were applied as train stimuli to activate release and then deplete GABA. Volatile and intravenous anesthetics had greater actions on inhibitory synaptic transmission in SAM-P8 than in SAM-R1, due to the increase in GABA release from presynaptic terminals.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (18 results) (of which Invited: 3 results) Book (2 results) Remarks (5 results)

  • [Journal Article] 吸入麻酔薬の作用機序2014

    • Author(s)
      佐々木利佳,廣田弘毅
    • Journal Title

      Anet

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 麻酔薬作用の修飾機序に関する電気生理学的アプローチ2013

    • Author(s)
      廣田弘毅,佐々木利佳
    • Journal Title

      臨床麻酔

      Volume: 37 Pages: 603-14

    • Related Report
      2013 Final Research Report
  • [Journal Article] 麻酔薬作用の修飾機序に関する電気生理学的アプローチ2013

    • Author(s)
      廣田弘毅,佐々木利佳
    • Journal Title

      臨床麻酔

      Volume: 37 Pages: 603-614

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Journal Article] 麻酔科医の目から見た医療安全のピットフォール2013

    • Author(s)
      廣田弘毅
    • Journal Title

      医報とやま

      Volume: 1576 Pages: 5-5

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Pre-synaptic function explains age-dependent actions of general anesthetics in the rat hippocampal synaptic transmission2012

    • Author(s)
      Hirota K, Sasaki R, Yamazaki M
    • Journal Title

      Toxicol In Vitro

      Volume: 26 Pages: 872-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre-synaptic function explains age-dependent actions of general anesthetics in the rat hippocampal synaptic transmission2012

    • Author(s)
      Hirota K, Sasaki R, et al.
    • Journal Title

      Toxicology In Vitro

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dementia enhances inhibitory actions of general anesthetics in hippocampal synaptic transmission2011

    • Author(s)
      M Yamada
    • Journal Title

      ISRN Anesthesiology

      Volume: 2011 Pages: 5-5

    • DOI

      10.5402/2011/837937

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of barbiturate and benzodiazepine on hippocampal synaptic transmission in dementia model animals2011

    • Author(s)
      Sasaki R, Hirota K, Yamazaki M
    • Journal Title

      Minerva Medica

      Volume: 102S Pages: 96-96

    • Related Report
      2013 Final Research Report
  • [Journal Article] 全身麻酔薬作用の電気生理学的検討(特集「全身麻酔のメカニズム解明はどこまで進んだか?」)2011

    • Author(s)
      廣田弘毅,佐々木利佳
    • Journal Title

      麻酔

      Volume: 60 Pages: 574-81

    • Related Report
      2013 Final Research Report
  • [Journal Article] 全身麻酔薬作用の電気生理学的検討2011

    • Author(s)
      廣田弘毅, 佐々木利佳
    • Journal Title

      麻酔

      Volume: 60 Pages: 574-581

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of barbiturate and benzodiazepine on hippocampal synaptic transmission in dementia model animals2011

    • Author(s)
      Sasaki R, Hirota K, et al.
    • Journal Title

      Minerva Medica

      Volume: 102 Pages: 96-96

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presynaptic actions of general anesthetics are responsible for frequency-dependent modification of synaptic transmission in the rat hippocampal CA12010

    • Author(s)
      Hirota K, Sasaki R, Roth SH, Yamazaki M
    • Journal Title

      Anesth Analg

      Volume: 110 Pages: 1607-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presynaptic actions of general anesthetics are responsible for frequency-dependent modification of synaptic transmission in the rat hippocampal CA12010

    • Author(s)
      Hirota K, et al
    • Journal Title

      Anesthesia & Analgesia

      Volume: 110 Pages: 1607-1613

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 術前の認知障害が術後せん妄と認知機能に与える影響2014

    • Author(s)
      廣田弘毅
    • Organizer
      第61回日本麻酔科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 認知症は扁桃体と海馬の連携を修飾する ー扁桃体/海馬スライスを用いた神経科学的検討ー2014

    • Author(s)
      佐々木利佳,廣田弘毅,山崎光章
    • Organizer
      第61回日本麻酔科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 麻酔をめぐるミステリー2013

    • Author(s)
      廣田弘毅
    • Organizer
      富山大学眼科同門会
    • Place of Presentation
      富山
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 扁桃体機能は海馬における全身麻酔薬作用を修飾するー扁桃体/海馬複合体スライスを用いた検討ー2013

    • Author(s)
      佐々木利佳,廣田弘毅,山田正名,山崎光章
    • Organizer
      第60回日本麻酔科学会
    • Place of Presentation
      札幌, 最優秀演題賞受賞)
    • Related Report
      2013 Final Research Report
  • [Presentation] 扁桃体機能は海馬における全身麻酔薬作用を修飾する ー扁桃体/海馬複合体スライスを用いた検討ー2013

    • Author(s)
      佐々木利佳,廣田弘毅,山田正名,山崎光章
    • Organizer
      第60回日本麻酔科学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 麻酔をめぐるミステリー2013

    • Author(s)
      廣田弘毅
    • Organizer
      富山大学眼科同門会
    • Place of Presentation
      富山市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 認知障害は海馬シナプス伝達における全身麻酔作用を増強する2012

    • Author(s)
      佐々木利佳,廣田弘毅,山田正名,山崎光章
    • Organizer
      第59回日本麻酔科学会
    • Place of Presentation
      神戸, (優秀演題)
    • Related Report
      2013 Final Research Report
  • [Presentation] 認知障害は海馬シナプス伝達における全身麻酔作用を増強する2012

    • Author(s)
      佐々木利佳
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Age-dependent effects of barbiturate and benzodiazepine on hippocampal synaptic transmission in the rats2011

    • Author(s)
      Hirota K, Sasaki R, Yamazaki M
    • Organizer
      World Anesthesia Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of barbiturate and benzodiazepine on hippocampal synaptic transmission in dementia model animals2011

    • Author(s)
      Sasaki R, Hirota K, Yamazaki M
    • Organizer
      World Anesthesia Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] AGE-DEPENDENT EFFECTS OF BARBITUBATE AND BENZODIAZEPINE ON HIPPOCAMPAL SYNAPTIC TRANSMISSION IN THE RATS2011

    • Author(s)
      Hirota K, Sasaki R, et al.
    • Organizer
      World Anesthesia Congress
    • Place of Presentation
      ローマ,イタリア
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of barbiturate and benzodiazepine on hippocampal synaptic transmission in dementia model animals2011

    • Author(s)
      Sasaki R, Hirota K, et al.
    • Organizer
      World Anesthesia Congress
    • Place of Presentation
      ローマ,イタリア
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of new benzodiazepine receptor agonist, JM-1232(-), on hippocampal synaptic transmission in the elderly and dementia model animals2010

    • Author(s)
      Hirota K, et al
    • Organizer
      8th International Conference on Mechanisms of Anesthesia
    • Place of Presentation
      トロント大学,カナダ
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Senile dementia enhances the actions of general anesthetics on hippocampal synaptic transmission2010

    • Author(s)
      Sasaki R, Hirota K, et al
    • Organizer
      8th International Conference on Mechanisms of Anesthesia
    • Place of Presentation
      トロント大学,カナダ
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢シナプス伝達に及ぼす全身麻酔薬の作用とその臨床的考察2010

    • Author(s)
      廣田弘毅
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢シナプス伝達に及ぼす全身麻酔薬の作用とその臨床的考察(シンポジウム「臨床に役立つ麻酔メカニズムBench to Bed, Bed to Bench」)2010

    • Author(s)
      廣田弘毅
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of new benzodiazepine receptor agonist, JM-1232(-), on hippocampal synaptic transmission in the elderly and dementia model animals2010

    • Author(s)
      Hirota K, Sasaki R, Iwase Y, Yamazaki M
    • Organizer
      The 8th International Conference on Mechanisms of Anesthesia
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Senile dementia enhances the actions of general anesthetics on hippocampal synaptic transmission2010

    • Author(s)
      Sasaki R, Hirota K, Iwase Y, Yamazaki M
    • Organizer
      The 8th International Conference on Mechanisms of Anesthesia
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Final Research Report
  • [Book] 麻酔をめぐるミステリー《手術室の「魔法」を解き明かす》2012

    • Author(s)
      廣田弘毅
    • Total Pages
      208
    • Publisher
      化学同人, (京都)
    • Related Report
      2013 Final Research Report
  • [Book] 麻酔をめぐるミステリー:手術室の「魔法」を解き明かす2012

    • Author(s)
      廣田弘毅
    • Total Pages
      208
    • Publisher
      化学同人(京都)
    • Related Report
      2012 Annual Research Report
  • [Remarks] Anesthetic Mechanism

    • URL

      http://doctor-koki.sakura.ne.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 全身麻酔のメカニズム

    • URL

      http://doctor-koki.sakura.ne.jp/Koki/Anesthetic_Mechanism/Anesthetic_Mechanism.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 全身麻酔のメカニズム

    • URL

      http://doctor-koki.sakura.ne.jp/Koki/Anesthetic_Mechanism/Anesthetic_Mechanism.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://web.me.com/morpheus_sq/iWeb/Koki/Anesthetic%20Mechanism/Anesthetic%20Mechanism.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.me.com/morpheus_sq/iWeb/Koki/Anesthetic%20Mechanism/Anesthetic%20Mechanism.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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