| Project/Area Number |
22591707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASHIMO Takashi 大阪大学, 大学院医学系研究科, 教授 (10110785)
SHIBUTA Satoshi (YANAGIDA Toshio) 大阪大学, 大学院医学系研究科, 助教 (20324767)
IWANE Atsuko 大阪大学, 生命機能研究科 (30252638)
柳田 敏雄 大阪大学, 生命機能研究科, 教授 (30089883)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 揮発性麻酔薬 / 幼若脳神経細胞障害 / 分子機構 / 1分子イメージング / １分子イメージング / 幼若神経細胞障害 |
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| Research Abstract |
In this study, we tried to find out the whole mechanism of the toxicity of volatile anesthetics to fetal rat brain. We speculated that volatile anesthetics might cause injury through inhibition of neurotrophins such as NGF or BDNF to bind to each receptor on the surface of the neuronal cells, or they might inhibit dimerization of the NGF/BDNF-receptor complexes.
We established the single Qdot-NGF/BDNF molecule live cell imaging system, and now analyzing if volatile anesthetics affect the binding of NGF or BDNF to each receptor or dimerization of the NGF/BDNF-receptor complexes.
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