Effects of Inhalational anesthetic exposure during pregnancy on neurodegeneration of neonatal mice

• Project/Area Number: 22591709
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kobe University
• Principal Investigator: UEKI Masaaki 神戸大学, 大学院・医学研究科, 医学研究員 (20213332)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 吸入麻酔薬 / 脳神経変性 / 妊娠 / BDNF / 8方向迷路学習 / マウス

Research Abstract

Exposure of 1% isoflurane on pregnant mice (embryonic day 17) had an influence on learning function, morphological synapse formation (synaptophysin staining) and BDNF mRNA on postnatal day 7. Furthermore, environmental enrichment improved learning function.

Research Products

• [Presentation] 環境エンリッチメントはイソフルラン麻酔後の脳発達障害を改善する (2011)
  • Author(s): 植木 正明, 森下 淳, 上嶋 江利, 魚川 礼子, 大井 まゆ, 前川 信博
  • Organizer: 第58回日本麻酔科学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-19
• [Presentation] 妊娠マウスへの吸入麻酔薬暴露は出生後の仔マウスに脳神経発達障害を及ぼす (2011)
  • Author(s): 上嶋 江利, 植木 正明, 森下 淳, 魚川 礼子, 大井 まゆ, 前川 信博
  • Organizer: 第58回日本麻酔科学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-19
• [Presentation] 妊娠マウスへの吸入麻酔薬暴露は出生後の仔マウスに脳神経発達障害を及ぼす (2011)
  • Author(s): 植木正明、上嶋江利, ほか
  • Organizer: 第58回日本麻酔科学会学術集会
  • Place of Presentation: 兵庫県神戸市、ポートピアホテル
  • Year and Date: 2011-05-19
• [Presentation] Erythropoietin Attenuates Isoflurane-Induced Neurodegeneration and Learning Deficits in Mouse Brain (2010)
  • Author(s): Teppei Tsuchimoto, Masaaki Ueki, Jun Morishita, Hiroyuki Miyazaki, Nobuhiro Maekawa
  • Organizer: American Society of anesthesiologists 2010 Annual Meeting.
  • Place of Presentation: San Diego、U.S.A.
  • Year and Date: 2010-10-19
• [Presentation] Isoflurane Induces Neurodegeneration in Younger Mice but Not with the Exposure for Shorter Duration. (2010)
  • Author(s): Jun Morishita, Masaaki Ueki, Teppei Tsuchimoto, Nobuhiro Maekawa
  • Organizer: Society of anesthesiologists 2010 Annual Meeting
  • Place of Presentation: San Diego、U.S.A.
  • Year and Date: 2010-10-19