| Project/Area Number |
22591714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
INOUE SATOKI 奈良県立医科大学, 医学部, 准教授 (50295789)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Masahiko 奈良県立医科大学, 医学部, 教授 (60275328)
FURUYA Hitoshi 奈良県立医科大学, 医学部, 教授 (70183598)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 脳虚血 / 脳蘇生 / βブロッカー / 蘇生学 |
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| Research Abstract |
The neuroprotective effects of pre- or post-ischemic administration of propranolol (a non-selective beta-adrenoreceptor antagonist), esmolol and landiolol (selective beta-adrenoreceptor 1 antagonists) against forebrain ischemia were investigated in rats. Methods: Intravenous administration of beta-blockers in male Sprague-Dawley rats was started 30 min before or 60 min after 8 min bilateral carotid artery occlusioncombined with hypotensionunder isoflurane anesthesia.The animals were evaluated neurologically and histologically after this 5-day period. Results: Pre-ischemic treatment with beta-blockers failed to provide neuroprotection. Post-ischemic treatment with esmolol and landiolol, but not with propranolol, reduced neuronal injury following forebrain ischemia. Conclusions: Post-ischemic treatment with esmolol and landiolol provided neuroprotection, whereas treatment with propranolol failed to show neuroprotection.
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