| Project/Area Number |
22591715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 聡己 奈良県立医科大学, 医学部, 准教授 (50295789)
古家 仁 奈良県立医科大学, 医学部, 教授 (70183598)
瓦口 至孝 (瓦口 佳孝) 奈良県立医科大学, 医学部, 講師 (90433333)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脊髄虚血 / ミクログリア / ミノサイクリン / ウサギ / 運動障害 / ラット |
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| Research Abstract |
Although minocycline has been shown to have neuroprotective effects in models of cerebral ischemia, there have been no data available regarding the effects of minocycline in a model of spinal cord ischemia (SCI). In the first study, we investigated the effects of minocycline in a rat model of SCI. Minocycline was intraperitoneally administered for 3 days beginning at 12 hours before 10 minutes of SCI. The results indicated that minocycline administration improved hind-limb motor function and attenuated gray and white matter injury. In the second study, we investigate whether postischemic administration of minocycline attenuates hind-limb motor dysfunction and gray and white matter injuries after SCI in rabbits. The results indicated that minocycline administration beginning at 1 hour after reperfusion improved hind-limb motor dysfunction and attenuated gray matter injury after SCI in rabbits. These results indicated that minocycline can be a candidate for neuroprotection for SCI.
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