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Cardio-protective effects of ulinastatin in isolated rat hearts

Research Project

Project/Area Number 22591724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Yamanashi

Principal Investigator

OGUCHI Takeshi  山梨大学, 大学院・医学工学総合研究部, 准教授 (60201399)

Co-Investigator(Kenkyū-buntansha) ISHIYAMA Tadahiko  山梨大学, 医学部付属病院, 准教授 (90293448)
MATSUKAWA Takashi  山梨大学, 大学院・医学工学総合研究部, 教授 (80209519)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords周術期管理学 / ウリナスタチン / 心筋虚血 / TNF-α / 心筋保護 / 摘出心筋 / 摘出心臓 / 虚血再灌流 / 虚血再灌流不整脈
Research Abstract

Pretreatment with ulinastatin, a clinically available proteaseinhibitor, offers protective effects against ischemia-reperfusion injury and protamine- induced cardiotoxicity by inhibiting TNF-alpha in the isolated rat heart.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Presentation (4 results) Remarks (2 results)

  • [Presentation] Ulinastatin, a protease inhibitor, attenuates protamine- induced cardiotoxicity in rats by inhibiting tumor necrosis factor alpha.2011

    • Author(s)
      Hisashi Fukushima, Takeshi Oguchi,, Hiroaki Sato, Tamaki Sato, Takashi Matsukawa.
    • Organizer
      2011 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      McCormick Place (アメリカ合衆国 シカゴ)
    • Year and Date
      2011-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Ulinastatin, A Protease Inhibitor, Attenuates Protamine-Induced Cardiotoxicity in Rats by Inhibiting Tumor Necrosis Factor Alpha2011

    • Author(s)
      福島久史
    • Organizer
      2011年アメリカ麻酔学会年次集会
    • Place of Presentation
      McCormick Place(アメリカ合衆国シカゴ)
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ulinastatin attenuates ischemia- reperfusion injury in the isolated rat heart2010

    • Author(s)
      Hisashi Fukushima, Takeshi Oguchi,, Tadahiki Ishiyama, Hiroaki Sato, Takashi Matsukawa.
    • Organizer
      2011 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      アメリカ合衆国 サンディエゴ
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Ulinastatin Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Hear2010

    • Author(s)
      福島久史
    • Organizer
      2010年アメリカ麻酔学会年次集会
    • Place of Presentation
      アメリカ合衆国サンディエゴ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://y-anesth.jp/research/shinkin/

    • Related Report
      2012 Final Research Report
  • [Remarks] 研究の紹介-ラットの摘出心臓標本

    • URL

      http://y-anesth.jp/research/shinkin/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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