Cardio-protective effects of ulinastatin in isolated rat hearts

• Project/Area Number: 22591724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of Yamanashi
• Principal Investigator: OGUCHI Takeshi 山梨大学, 大学院・医学工学総合研究部, 准教授 (60201399)
• Co-Investigator(Kenkyū-buntansha): ISHIYAMA Tadahiko 山梨大学, 医学部付属病院, 准教授 (90293448) ; MATSUKAWA Takashi 山梨大学, 大学院・医学工学総合研究部, 教授 (80209519)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 周術期管理学 / ウリナスタチン / 心筋虚血 / TNF-α / 心筋保護 / 摘出心筋 / 摘出心臓 / 虚血再灌流 / 虚血再灌流不整脈

Research Abstract

Pretreatment with ulinastatin, a clinically available proteaseinhibitor, offers protective effects against ischemia-reperfusion injury and protamine- induced cardiotoxicity by inhibiting TNF-alpha in the isolated rat heart.

Research Products

• [Presentation] Ulinastatin, a protease inhibitor, attenuates protamine- induced cardiotoxicity in rats by inhibiting tumor necrosis factor alpha. (2011)
  • Author(s): Hisashi Fukushima, Takeshi Oguchi,, Hiroaki Sato, Tamaki Sato, Takashi Matsukawa.
  • Organizer: 2011 Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: McCormick Place (アメリカ合衆国 シカゴ)
  • Year and Date: 2011-10-16
• [Presentation] Ulinastatin, A Protease Inhibitor, Attenuates Protamine-Induced Cardiotoxicity in Rats by Inhibiting Tumor Necrosis Factor Alpha (2011)
  • Author(s): 福島久史
  • Organizer: 2011年アメリカ麻酔学会年次集会
  • Place of Presentation: McCormick Place(アメリカ合衆国シカゴ)
  • Year and Date: 2011-10-16
• [Presentation] Ulinastatin attenuates ischemia- reperfusion injury in the isolated rat heart (2010)
  • Author(s): Hisashi Fukushima, Takeshi Oguchi,, Tadahiki Ishiyama, Hiroaki Sato, Takashi Matsukawa.
  • Organizer: 2011 Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: アメリカ合衆国 サンディエゴ
  • Year and Date: 2010-10-17
• [Presentation] Ulinastatin Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Hear (2010)
  • Author(s): 福島久史
  • Organizer: 2010年アメリカ麻酔学会年次集会
  • Place of Presentation: アメリカ合衆国サンディエゴ
  • Year and Date: 2010-10-17
• [Remarks]
  • URL: http://y-anesth.jp/research/shinkin/
• [Remarks] 研究の紹介－ラットの摘出心臓標本
  • URL: http://y-anesth.jp/research/shinkin/