| Project/Area Number |
22591727
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SHIBATA Masahiko 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (50216016)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Youichi 大阪大学, 医学(系)研究科(研究院), 助教 (00397754)
INOUE Takaya 大阪大学, 医学系研究科, 寄附講座助教 (00335358)
SAKAUE Manabu 大阪大学, 医学系研究科, 助教 (70379254)
UEMATSU Hironobu 大阪大学, 医学部付属病院, 医員 (70467554)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 恐怖条件付け / 皮膚電位反射 / 運動時痛 / 筋痛 / 運動 / 皮膚電気抵抗 / 動的機械刺激 / fMRI / 条件付け / 痛み / f・MRI / 脳機能画像 |
|---|
| Research Abstract |
he fear-avoidance model assumes that fear conditioning to movement with pain underlies development of musculoskeletal chronic pain. Our study verified this using fear conditioning. During conditioning, 8 healthy subjects (mean age, 27.4 years) voluntarily moved their hands and received painful heat stimuli with a probability of 3/5 times. To evaluate the fear of pain, skin potential response (SPR) and numerical rating scale (NRS) scores were calculated. The SPR amplitude and incidence, and NRS score in the trials devoid of the painful stimuli were compared between trials with and without hand movements. All indices in the trials with hand movements were significantly higher than those in the trials without (amplitude: 6.71 ± 3.70 mV versus 3.75 ± 3.06 mV, p < 0.05; incidence: 88.9 ± 16.1% versus 44.5 ± 28.5%, p < 0.01; NRS score: 4.25 ± 2.81 versus 1.33 ± 1.09, p < 0.05). Furthermore, the mean peak latency of SPR following the painful stimuli significantly decreased after conditioning (2.73 ± 0.36 s versus 1.75 ± 0.36 s, p < 0.01), indicating that fear of pain can be associated with voluntary movements inducing pain. This finding supports the fear-avoidance model.
|
