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The analysis and treatment of immuno-suppressive state in cellular immunity induced by sepsis

Research Project

Project/Area Number 22591728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

OHTA Noriyuki  大阪大学, 医学部附属病院, 助教 (60379162)

Co-Investigator(Kenkyū-buntansha) FUJINO Yuji  大阪大学, 大学院・医学系研究科, 教授 (50252672)
GOTO Yukiko  大阪大学, 大学院・医学系研究科, 助教 (20276710)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords敗血症 / 免疫応答 / 細胞傷害性リンパ球 / 粘膜免疫 / サイトカイン / PD-L1 / コレラ毒素 / 細胞性免疫 / マウス / 腹膜炎 / 鎮静薬 / 樹状細胞 / 腫瘍
Research Abstract

We analyzed the immunosuppressive state after recovery from sepsis induced by peritonitis in mice. We mainly used experimental system analyzing antigen-specific immune-response induced by mucosal immunization method. In mice recovered from sepsis, antigen-specific immune-response was depressed in terms of cellular immunity. Furthermore, we tried the improvement of depressed immune-response by intervention into PD-1 and PD-L1 signalling.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (11 results)

  • [Journal Article] The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury2013

    • Author(s)
      Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y.
    • Journal Title

      Crit Care Med

      Volume: 41 Pages: 536-45

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury.2012

    • Author(s)
      Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y
    • Journal Title

      Crit Care Med.

      Volume: 40 Pages: 1578-85

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming of lipopolysaccharide-induced t helper 1-type immune response.2011

    • Author(s)
      Ohta N, Ohashi Y, Takayama C, Mashimo T, Fujino Y.
    • Journal Title

      Anesthesiology.

      Volume: 114 Pages: 355-62

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of ventilator performance on airway pressure release ventilation: a model lung study2011

    • Author(s)
      Yoshida T, Uchiyama A, Mashimo T, Fujino Y.
    • Journal Title

      Anesth Analg

      Volume: 113 Pages: 529-33

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming of lipopolysaccharide-induced T helper-1 type immune response2011

    • Author(s)
      大田典之, 藤野裕士
    • Journal Title

      Anesthesiology

      Volume: 114 Pages: 355-362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of ventilator performance on airway pressure release ventilation : alung model study2011

    • Author(s)
      藤野裕士
    • Journal Title

      Anesthesia and Analgesia

      Volume: 113 Pages: 529-533

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming of lipopolysaccharide-induced t helper 1-type immune response2011

    • Author(s)
      大田典之、藤野裕士
    • Journal Title

      Anesthesiology.

      Volume: 114 Pages: 355-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Propofol has anti-inflammatory effects on alveolar type II epithelial cells2010

    • Author(s)
      馬鈴、藤野裕士
    • Journal Title

      Acta Anaesthesiol Scand.

      Volume: 54 Pages: 362-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of performance of two high-frequency oscillatory ventilators using a model lung with a position sensor.2010

    • Author(s)
      井口直也、藤野裕士
    • Journal Title

      J Anesth

      Volume: 24 Pages: 888-92

    • NAID

      10027741404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of continuous venovenous hemofiltration on the pharmacology of carperitide, a recombinant-human atrial natriuretic peptide2010

    • Author(s)
      高橋りょう子、藤野裕士
    • Journal Title

      Circ J

      Volume: 74 Pages: 1888-92

    • NAID

      10026971432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous breathing during lung protective ventilation in experimental acute lung injury model : high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury

    • Author(s)
      藤野裕士
    • Journal Title

      Critical Care Medicine

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミダゾラムは樹状細胞による抗原特異的な免疫応答を抑制する2013

    • Author(s)
      大田典之
    • Organizer
      第40回日本集中治療医学会総会
    • Place of Presentation
      松本
    • Year and Date
      2013-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] ミダゾラムは樹状細胞による抗原特異的な応答を抑制する2013

    • Author(s)
      大田典之
    • Organizer
      第40回日本集中治療医学会学術総会
    • Place of Presentation
      松本
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロポフォールは樹状細胞によって誘導される Th1 型免疫応答を促進する2012

    • Author(s)
      大田典之
    • Organizer
      第59回日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 敗血症は粘膜免疫応答を低下させる2012

    • Author(s)
      大田典之
    • Organizer
      第39回日本集中治療医学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 敗血症は粘膜免疫応答を低下させる2012

    • Author(s)
      大田典之, 藤野裕士
    • Organizer
      日本集中治療医学会総会
    • Place of Presentation
      幕張(千葉)(招待講演)
    • Year and Date
      2012-03-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロポフォールは樹状細胞によって惹起されるTh1型免疫応答を増強する2012

    • Author(s)
      大田典之, 藤野裕士
    • Organizer
      日本集中治療医学会総会
    • Place of Presentation
      幕張(千葉)(招待講演)
    • Year and Date
      2012-03-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロポフォールは樹状細胞によって誘導されるTh1型免疫応答を促進する2012

    • Author(s)
      大田典之
    • Organizer
      第59回日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 樹状細胞の機能に対する鎮静薬の機能の多様性2011

    • Author(s)
      大田典之
    • Organizer
      第38回日本集中治療医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ミダゾラムは樹状細胞によって惹起されるTh1 型の免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      第57回日本麻酔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ミダゾラムは樹状細胞によって惹起されるTh1型の免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミダゾラムは自己非自己の認識能を低下させる2010

    • Author(s)
      大田典之
    • Organizer
      第60回日本麻酔科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-05-23
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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